微波条件下苄基溴的铃木-宫浦交叉偶联反应
Suzuki-Miyaura Cross-Coupling of Benzylic Bromides Under Microwave Conditions.
作者信息
McDaniel Steven W, Keyari Charles M, Rider Kevin C, Natale Nicholas R, Diaz Philippe
机构信息
Core Laboratory for Neuromolecular Production, Dept. of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, Montana 59803, United States.
出版信息
Tetrahedron Lett. 2011 Oct 26;52(43):5656-5658. doi: 10.1016/j.tetlet.2011.08.096.
Abstract
A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.
摘要
已开发出一种在微波条件下进行苄基铃木-宫浦交叉偶联的方法。这些条件使得杂环化合物能够进行偶联。发现的最佳条件是使用醋酸钯（Pd(OAc)(2)）、约翰膦（JohnPhos）作为催化剂和配体、碳酸钾作为碱以及N,N-二甲基甲酰胺（DMF）作为溶剂。利用这些条件，合成了一系列结构多样的化合物库。
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