Department of Nephrology, Faculty of Medicine, Baskent University, Adana Teaching and Medical Research Center, Adana, Turkey.
Clin Exp Hypertens. 2012;34(3):171-5. doi: 10.3109/10641963.2011.577489. Epub 2011 Oct 3.
The aim of this study was to investigate whether inflammatory markers are associated with hypertensive end organ damage or obesity in patients with hypertension. Seventy newly diagnosed essential hypertensive patients (29 men and 41 women aged 49.6 ± 9.5 y) and 25 age-sex-matched normotensive subjects (12 men and 13 women aged 45.8 ± 7.3 y) were asked about their family history of hypertension and smoking habits, and body mass index (BMI) was recorded and blood samples were taken to measure fibrinogen, C-reactive protein (CRP), and homocysteine levels. In hypertensive patients, creatinine clearance, urinary albumin extraction, and left ventricular mass index were determined. Hypertensive patients had significantly higher BMIs and inflammatory markers when compared with normotensive healthy controls. The CRP was positively associated with BMI (P < .05), diastolic blood pressure (P < .05), fibrinogen (P < .01), urinary albumin extraction (P < .01), and left ventricular mass index (P < .05). The BMI and serum fibrinogen level were independently associated with CRP. The effect of inflammation on the development of hypertensive end organ damage may be associated with obesity, so that control of obesity may eliminate the inflammatory state in hypertensive patients and also hypertensive end organ damage.
本研究旨在探讨炎症标志物与高血压患者的高血压终末器官损害或肥胖之间是否存在相关性。70 例新诊断的原发性高血压患者（29 名男性，41 名女性，年龄 49.6±9.5 岁）和 25 名年龄、性别匹配的血压正常受试者（12 名男性，13 名女性，年龄 45.8±7.3 岁）被问及高血压家族史和吸烟习惯，记录体重指数（BMI），采集血样以测量纤维蛋白原、C 反应蛋白（CRP）和同型半胱氨酸水平。在高血压患者中，还测定了肌酐清除率、尿白蛋白排泄率和左心室质量指数。与血压正常的健康对照组相比，高血压患者的 BMI 和炎症标志物显著更高。CRP 与 BMI（P<.05）、舒张压（P<.05）、纤维蛋白原（P<.01）、尿白蛋白排泄率（P<.01）和左心室质量指数（P<.05）呈正相关。BMI 和血清纤维蛋白原水平与 CRP 独立相关。炎症对高血压终末器官损害发展的影响可能与肥胖有关，因此控制肥胖可能会消除高血压患者的炎症状态和高血压终末器官损害。
