Lynch H T, Fitzgibbons R J, Lynch J F
Creighton University School of Medicine, Omaha, Nebraska.
Surg Clin North Am. 1990 Aug;70(4):753-74. doi: 10.1016/s0039-6109(16)45183-2.
The properly compiled cancer family history can prove to be one of the most cost-effective and powerful instruments for cancer control in breast cancer. Needed, however, is an understanding of the heterogeneity of hereditary breast cancer and knowledge of those facets of its natural history that can expedite a syndrome diagnosis. Priority concerns for cancer control in hereditary breast cancer are the development of registries of cancer-prone families, willingness by third-party carriers to help defray the costs of surveillance, and more research in molecular genetics.
妥善编制的癌症家族史可能会被证明是乳腺癌防控中最具成本效益和最有效的手段之一。然而，需要了解遗传性乳腺癌的异质性以及其自然史中那些可加速综合征诊断的方面。遗传性乳腺癌防控的首要关注点是建立癌症易患家族登记册、第三方承保机构愿意帮助支付监测费用以及在分子遗传学方面开展更多研究。
