Department of Orthodontics, Center of Dental Sciences, Gulhane Military Medical Academy, Ankara, Turkey.
Am J Orthod Dentofacial Orthop. 2011 Oct;140(4):e147-53. doi: 10.1016/j.ajodo.2011.02.022.
The aims of this study were to evaluate the effect of a self-etching adhesive system containing an antibacterial monomer on periodontal health and subgingival microbiologic composition in orthodontic patients and to compare it with a conventional adhesive system.
A split-mouth design was chosen, and 15 patients were included in the study. Brackets in contralateral quadrants were bonded with either a conventional adhesive system (control) or a self-etching adhesive system that contained an antibacterial monomer. Clinical periodontal parameters including plaque index, gingival index, probing depths, and bleeding on probing were determined. Subgingival plaque samples were collected before bracket placement (T0) and at the 6-month follow-up (T1). The real-time TaqMan polymerase chain reaction assay was used to determine the subgingival counts of Porphyromonas gingivalis, Tannerella forsythensis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Campylobacter rectus. For clinical periodontal parameters, analysis of covariance (ANCOVA) and, for bacterial counts, Wilcoxon tests were used for statistical comparisons at the P <0.05 level.
Clinical periodontal parameters were not changed, and they were not different between the groups from T0 to T1. T forsythensis and F nucleatum increased during the treatment period in both groups (P <0.05). The majority of the bacteria were T nucleatum at T0 and T1 in both groups. Changes in bacterial load from T0 to T1 were not different between groups except for T forsythensis and F nucleatum (P <0.05).
The use of an antibacterial monomer did not have an additional positive effect on clinical periodontal parameters. When used in bonding orthodontic brackets, the antibacterial monomer failed to reduce periodontopathogenic bacteria when compared with the conventional adhesive system during a 6-month treatment period.
本研究旨在评估含有抗菌单体的自酸蚀粘接系统对正畸患者牙周健康和龈下微生物组成的影响，并将其与传统粘接系统进行比较。
采用分口设计，纳入 15 名患者。对相对象限的托槽分别用传统粘接系统（对照组）或含有抗菌单体的自酸蚀粘接系统进行粘接。记录菌斑指数、牙龈指数、探诊深度和探诊出血等临床牙周参数。在托槽放置前（T0）和 6 个月随访时（T1）采集龈下菌斑样本。采用实时 TaqMan 聚合酶链反应检测龈下菌斑中牙龈卟啉单胞菌、福赛斯坦纳菌、中间普氏菌、伴放线放线杆菌、核梭杆菌和直肠弯曲菌的数量。对于临床牙周参数，采用协方差分析（ANCOVA），对于细菌计数，采用 Wilcoxon 检验进行统计学比较，P<0.05 为差异有统计学意义。
临床牙周参数在治疗期间未发生变化，且两组间从 T0 到 T1 也无差异。两组中 T forsythensis 和 F nucleatum 在治疗期间均增加（P<0.05）。两组中 T0 和 T1 时主要细菌均为 T nucleatum。除 T forsythensis 和 F nucleatum 外（P<0.05），两组从 T0 到 T1 的细菌载量变化无差异。
使用抗菌单体对临床牙周参数没有额外的积极影响。在正畸托槽粘接中，与传统粘接系统相比，抗菌单体在 6 个月的治疗期间并不能减少牙周致病菌。
