Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
Fitoterapia. 2012 Jan;83(1):49-54. doi: 10.1016/j.fitote.2011.09.012. Epub 2011 Sep 24.
Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 μg/mL, whereas compound 1 was most active against HL-60 cell line with IC(50) value of 0.94 ± 0.26 μg/mL.
对牡荆种子的化学成分研究得到了一个新的呋喃-containing 倍半萜，negunfurol（1），一个新的 norlabdane 型二萜，negundoal（2），和两个新的 norursane 型三萜，negundonorins A（3）和 B（4），以及两个已知的化合物，3-甲酰基-4,5-二甲基-8-氧代-5H-6,7-二氢萘并[2,3-b]呋喃（5）和 3-epi- 齐墩果酸（6）。它们的结构和构型是根据 NMR、IR 和 MS 数据的详细光谱分析确定的。化合物 3 对 ZR-75-30 细胞系具有强烈的细胞毒性，IC（50）值为 0.56±0.19μg/ml，而化合物 1 对 HL-60 细胞系的活性最强，IC（50）值为 0.94±0.26μg/ml。
