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肝原发性神经内分泌肿瘤行肝切除术治疗 1 例报告

Primary neuroendocrine tumor in the liver treated by hepatectomy: report of a case.

机构信息

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

出版信息

Surg Today. 2011 Dec;41(12):1655-60. doi: 10.1007/s00595-011-4497-z. Epub 2011 Oct 4.

DOI:10.1007/s00595-011-4497-z
PMID:21969201
Abstract

A 49-year-old woman was admitted to our hospital under suspicion of an enlarging hepatic tumor, which had been previously diagnosed to be a cavernous hemangioma. Computed tomography revealed three enhanced tumors, one measuring 15 cm in diameter within the right lobe of the liver and two intrahepatic metastases in Couinaud's hepatic segments 3 and 5. We diagnosed the patient to have primary liver cancer, and suspected a combined liver tumor preoperatively. We performed a right trisectionectomy with radiofrequency ablation of the intrahepatic metastasis in S3. According to the immunohistochemical findings of the resected specimen and the findings of postoperative imaging studies, the tumor was diagnosed to be a primary neuroendocrine tumor in the liver. The patient is presently alive without recurrence at 33 months after the operation.

摘要

一位 49 岁女性因疑似肝肿瘤增大而被收入我院,该肿瘤此前被诊断为海绵状血管瘤。计算机断层扫描显示三个增强肿瘤,一个位于肝右叶直径 15 厘米,两个肝内转移位于 Couinaud 的肝段 3 和 5。我们诊断为原发性肝癌,并怀疑术前为肝联合肿瘤。我们进行了右三叶切除术,并对 S3 的肝内转移进行射频消融。根据切除标本的免疫组化结果和术后影像学研究结果,肿瘤被诊断为原发性肝神经内分泌肿瘤。术后 33 个月,患者无复发,目前仍存活。

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本文引用的文献

1
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases.原发性肝神经内分泌癌 11 例临床分析。
Hepatobiliary Pancreat Dis Int. 2010 Feb;9(1):44-8.
2
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case.肝脏原发性神经内分泌癌合并血管瘤 1 例报告。
Surg Today. 2010;40(2):185-9. doi: 10.1007/s00595-009-4018-5. Epub 2010 Jan 28.
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Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group.
一例罕见神经内分泌性肝肿瘤经CT引导下肝活检后发生的产气荚膜梭菌菌血症和脓毒症致死病例。
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Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review.肝脏中混合性神经内分泌癌与肝细胞癌的组织学特征:一例报告及文献复习
Clin J Gastroenterol. 2016 Aug;9(4):272-9. doi: 10.1007/s12328-016-0669-0. Epub 2016 Jul 6.
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Primary hepatic neuroendocrine tumor: A case report.原发性肝神经内分泌肿瘤:一例报告。
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Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule.一个结节中具有胆管细胞癌成分的原发性肝神经内分泌癌。
Clin J Gastroenterol. 2014 Oct;7(5):449-54. doi: 10.1007/s12328-014-0521-3. Epub 2014 Aug 13.
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Primary hepatic neuroendocrine carcinoma.原发性肝神经内分泌癌
Korean J Hepatobiliary Pancreat Surg. 2013 Feb;17(1):34-7. doi: 10.14701/kjhbps.2013.17.1.34. Epub 2013 Feb 28.
8
Elevated serum levels of Chromogranin A in hepatocellular carcinoma.肝细胞癌患者血清嗜铬粒蛋白A水平升高。
BMC Surg. 2012;12 Suppl 1(Suppl 1):S7. doi: 10.1186/1471-2482-12-S1-S7. Epub 2012 Nov 15.
奥曲肽长效注射剂(LAR)对转移性中肠神经内分泌肿瘤患者肿瘤生长控制效果的安慰剂对照、双盲、前瞻性、随机研究:PROMID研究组报告
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Primary hepatic carcinoid tumor: a case report and review of the literature.原发性肝类癌肿瘤:一例病例报告及文献综述
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Virchows Arch. 2006 Sep;449(3):376-81. doi: 10.1007/s00428-006-0251-0. Epub 2006 Aug 1.
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Endocrine tumours of the gastrointestinal tract. Introduction: definition, historical aspects, classification, staging, prognosis and therapeutic options.胃肠道内分泌肿瘤。引言:定义、历史回顾、分类、分期、预后及治疗选择。
Best Pract Res Clin Gastroenterol. 2005 Aug;19(4):491-505. doi: 10.1016/j.bpg.2005.03.006.
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Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system.生长抑素类似物用于胃肠胰系统神经内分泌肿瘤管理的共识报告
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