Kevadiya B D, Patel H A, Joshi G V, Abdi S H R, Bajaj H C
Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research, G. B. Marg, Bhavnagar - 364 021, India.
Indian J Pharm Sci. 2010 Nov;72(6):732-7. doi: 10.4103/0250-474X.84582.
Diclofenac sodium and alginate was intercalated into montmorillonite to form uniform sized beads by gelation method. The structure and surface morphology of the synthesized composite beads were characterized by powdered X-ray diffraction, Fourier transform infrared spectroscopy, thermo gravimetric analysis and scanning electron microscopy. Diclofenac release kinetics of the composite in simulated intestinal fluid medium (pH 7.4) and effect of montmorillonite content on the in vitro release of diclofenac from diclofenac-montmorillonite-alginate composites bead was investigated by UV/Vis spectrophotometer. Diclofenac encapsulation efficiency in the montmorillonite-alginate composites bead increases with an increase in the montmorillonite content. The control release of diclofenac from diclofenac-montmorillonite-alginate composites beads was observed to be better as compared to diclofenac-alginate beads.
将双氯芬酸钠和海藻酸盐插层到蒙脱石中，通过凝胶法形成尺寸均匀的珠子。采用粉末X射线衍射、傅里叶变换红外光谱、热重分析和扫描电子显微镜对合成的复合珠子的结构和表面形态进行了表征。用紫外可见分光光度计研究了该复合材料在模拟肠液介质（pH 7.4）中的双氯芬酸释放动力学以及蒙脱石含量对双氯芬酸从双氯芬酸-蒙脱石-海藻酸盐复合珠子中体外释放的影响。蒙脱石-海藻酸盐复合珠子中双氯芬酸的包封效率随蒙脱石含量的增加而提高。观察到与双氯芬酸-海藻酸盐珠子相比，双氯芬酸-蒙脱石-海藻酸盐复合珠子对双氯芬酸的控释效果更好。
