Hammerman Marc R
George M. O'Brien Center for Kidney Disease Research, Departments of Medicine, and Cell Biology and Physiology, The Washington University School of Medicine, St. Louis, MO 63110, USA.
J Transplant. 2011;2011:261352. doi: 10.1155/2011/261352. Epub 2011 Sep 28.
Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early following pancreatic primordium formation (embryonic day 28 (E28)) engraft long-term in non-immune, suppressed diabetic rats or rhesus macaques. Morphologically, similar cells originating from adult porcine islets of Langerhans (islets) engraft in non-immune-suppressed rats or rhesus macaques previously transplanted with E28 pig pancreatic primordia. Our data are consistent with induction of tolerance to an endocrine cell component of porcine islets induced by previous transplantation of embryonic pig pancreas, a novel finding we designate organogenetic tolerance. The potential exists for its use to enable the use of pigs as islet cell donors for humans with no immune suppression requirement.
糖尿病的移植治疗受到供体器官短缺以及免疫抑制药物毒性导致的复杂后果的限制。异种移植是克服供应问题的一种策略。植入胚胎发育早期获得的组织是降低移植免疫原性的一种方法。源自猪胰腺原基形成后很早时间（胚胎第28天（E28））获得的胚胎猪胰腺的产胰岛素细胞能长期植入非免疫、受抑制的糖尿病大鼠或恒河猴体内。在形态学上，源自成年猪胰岛的类似细胞能植入先前已移植E28猪胰腺原基的非免疫抑制大鼠或恒河猴体内。我们的数据与先前移植胚胎猪胰腺诱导对猪胰岛内分泌细胞成分产生耐受性一致，这是一个我们称为器官发生耐受性的新发现。其有可能用于使猪作为人类胰岛细胞供体而无需免疫抑制。
