Department of Psychiatry, Washington University School of Medicine St. Louis, St. Louis, MO 63110, USA.
Parkinsons Dis. 2011;2011:742907. doi: 10.4061/2011/742907. Epub 2011 Sep 28.
Background. Brain regions subserving emotion have mostly been studied using functional magnetic resonance imaging (fMRI) during emotion provocation procedures in healthy participants. Objective. To identify neuroanatomical regions associated with spontaneous changes in emotional state over time. Methods. Self-rated emotional valence and arousal scores, and regional cerebral blood flow (rCBF) measured by perfusion MRI, were measured 4 or 8 times spanning at least 2 weeks in each of 21 subjects with Parkinson's disease (PD). A random-effects SPM analysis, corrected for multiple comparisons, identified significant clusters of contiguous voxels in which rCBF varied with valence or arousal. Results. Emotional valence correlated positively with rCBF in several brain regions, including medial globus pallidus, orbital prefrontal cortex (PFC), and white matter near putamen, thalamus, insula, and medial PFC. Valence correlated negatively with rCBF in striatum, subgenual cingulate cortex, ventrolateral PFC, and precuneus-posterior cingulate cortex (PCC). Arousal correlated positively with rCBF in clusters including claustrum-thalamus-ventral striatum and inferior parietal lobule and correlated negatively in clusters including posterior insula-mediodorsal thalamus and midbrain. Conclusion. This study demonstrates that the temporal stability of perfusion MRI allows within-subject investigations of spontaneous fluctuations in mental state, such as mood, over relatively long-time intervals.
情绪相关的脑区主要通过健康参与者在情绪诱发过程中使用功能磁共振成像（fMRI）进行研究。目的：确定与情绪随时间自发变化相关的神经解剖区域。方法：21 名帕金森病（PD）患者至少在 2 周内进行 4 次或 8 次自我评估的情绪效价和唤醒评分以及灌注 MRI 测量的局部脑血流（rCBF）。采用随机效应 SPM 分析，校正多重比较，确定与效价或唤醒相关的连续体素显著簇。结果：情绪效价与多个脑区的 rCBF 呈正相关，包括内侧苍白球、眶额皮质（PFC）和靠近壳核、丘脑、岛叶和内侧 PFC 的白质。纹状体、扣带回下皮质、腹外侧 PFC 和楔前叶-后扣带回皮质（PCC）的 rCBF 与效价呈负相关。唤醒与包括屏状核-丘脑-腹侧纹状体和下顶叶在内的簇中的 rCBF 呈正相关，与包括后岛叶-中脑导水管周围灰质和中脑在内的簇中的 rCBF 呈负相关。结论：本研究表明，灌注 MRI 的时间稳定性允许在相对长的时间间隔内对精神状态（如情绪）的自发波动进行个体内研究。
