Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA.
Arch Pathol Lab Med. 2011 Oct;135(10):1261-8. doi: 10.5858/arpa.2011-0034-RA.
Appendiceal mucinous neoplasms are considered enigmatic tumors of unpredictable biologic potential. Their importance lies in their potential to spread to the peritoneum and viscera in the form of gelatinous mucin deposits. Extra-appendiceal spread of these tumors is the most common etiology of pseudomyxoma peritonei , which is a descriptive term encompassing a number of neoplastic and nonneoplastic peritoneal disorders. Many studies aimed at evaluating the biologic importance of appendiceal mucinous neoplasms and pseudomyxoma peritonei have employed inconsistent histologic criteria for their diagnosis and descriptive terminology for their classification. As a result, appendiceal mucinous neoplasms and associated peritoneal disease represents one of the most confusing and controversial areas in gastrointestinal pathology.
To summarize the literature regarding the biologic potential of appendiceal mucinous neoplasms and pseudomyxoma peritonei and to discuss the similarities and differences between proposed systems for their classification.
Literature review and case-derived material.
Many studies have contributed to an increased understanding of the natural progression of mucinous neoplasms of the appendix and peritoneum, and the adoption of a uniform reporting system, as advocated by the American Joint Committee on Cancer and the World Health Organization, will facilitate clear communication among pathologists and clinical colleagues.
阑尾黏液性肿瘤被认为是具有不可预测生物学潜能的神秘肿瘤。其重要性在于它们有可能以胶状黏液沉积的形式播散至腹膜和内脏。这些肿瘤的阑尾外播散是假性黏液瘤腹膜病的最常见病因，假性黏液瘤腹膜病是一个描述性术语，涵盖了许多肿瘤性和非肿瘤性腹膜疾病。许多旨在评估阑尾黏液性肿瘤和假性黏液瘤腹膜病生物学重要性的研究采用了不一致的组织学标准来诊断，并采用了不同的描述性术语来对其进行分类。因此，阑尾黏液性肿瘤及其相关腹膜疾病是胃肠道病理学中最令人困惑和最具争议的领域之一。
总结有关阑尾黏液性肿瘤和假性黏液瘤腹膜病生物学潜能的文献，并讨论用于其分类的不同建议系统之间的异同。
文献复习和病例衍生材料。
许多研究促进了对阑尾和腹膜黏液性肿瘤自然进展的深入了解，采用美国癌症联合委员会和世界卫生组织提倡的统一报告系统将有助于病理学家和临床同事之间进行清晰的交流。
