WNT 再探：β-连环蛋白和 TCFs 在多能性中的新面孔。
A WNTer revisit: new faces of β-catenin and TCFs in pluripotency.
机构信息
Department of Biological Chemistry, School of Medicine, D250 Med Sci I, University of California, Irvine, CA 92697-1700, USA.
出版信息
Sci Signal. 2011 Sep 27;4(193):pe41. doi: 10.1126/scisignal.2002436.
New evidence has revealed interesting aspects of how the Wnt-β-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt-β-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.
新证据揭示了 Wnt-β-catenin 通路如何控制多能胚胎干细胞的自我更新和谱系分化的有趣方面。虽然 Wnt-β-catenin 信号对于原始小鼠胚胎干细胞的自我更新不是必需的，但它通过涉及转录抑制因子 T 细胞因子 (TCF) 3 和转录激活因子 TCF1 的非传统双重机制促进其扩增和抵抗分化。
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