Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA.
Phys Med Biol. 2011 Nov 7;56(21):6809-22. doi: 10.1088/0031-9155/56/21/004. Epub 2011 Oct 5.
Despite its high sensitivity, the variable specificity of magnetic resonance imaging (MRI) in breast cancer diagnosis can lead to unnecessary biopsies and over-treatment. Scintimammography (SMM) could potentially supplement MRI to improve the diagnostic specificity. The synergistic combination of MRI and SMM (MRSMM) could result in both high sensitivity from MRI and high specificity from SMM. Development of such a dual-modality system requires the integration of a radio frequency (RF) coil and radiation detector in a strong magnetic field without significant mutual interference. In this study, we developed and tested a unilateral breast array coil specialized for MRSMM imaging. The electromagnetic field, specific absorption ratio and RF coil parameters with cadmium-zinc-telluride detectors encapsulated in specialized RF and gamma-ray shielding mounted within the RF coil were investigated through simulation and experimental measurements. Simultaneous MR and SMM images of a breast phantom were also acquired using the integrated MRSMM system. This work, we feel, represents an important step toward the fabrication of a working MRSMM system.
尽管磁共振成像（MRI）在乳腺癌诊断中具有很高的灵敏度，但它的特异性却存在变化，这可能导致不必要的活检和过度治疗。闪烁乳腺成像（SMM）有可能补充 MRI 以提高诊断的特异性。MRI 和 SMM 的协同组合（MRSMM）可以结合 MRI 的高灵敏度和 SMM 的高特异性。这种双模态系统的开发需要在强磁场中集成射频（RF）线圈和辐射探测器，而不会产生明显的相互干扰。在这项研究中，我们开发并测试了一种专门用于 MRSMM 成像的单侧乳腺阵列线圈。通过模拟和实验测量，研究了封装在专门的 RF 和伽马射线屏蔽中的碲化镉锌探测器的电磁场、比吸收率和 RF 线圈参数。还使用集成的 MRSMM 系统获取了乳腺体模的同时 MR 和 SMM 图像。我们认为，这项工作是朝着制造工作的 MRSMM 系统迈出的重要一步。
