Tu and Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall Irvine, CA 92697-5020 USA.
Technol Cancer Res Treat. 2010 Feb;9(1):21-8. doi: 10.1177/153303461000900103.
Single-photon emission computed tomography (SPECT) can provide specific functional information while magnetic resonance imaging (MRI) can provide high-spatial resolution anatomical information as well as complementary functional information. In this study, we utilized a dual modality SPECT/MRI (MRSPECT) system to investigate the integration of SPECT and MRI for improved image accuracy. The MRSPECT system consisted of a cadmium-zinc-telluride (CZT) nuclear radiation detector interfaced with a specialized radiofrequency (RF) coil that was placed within a whole-body 4 T MRI system. The importance of proper corrections for non-uniform detector sensitivity and Lorentz force effects was demonstrated. MRI data were utilized for attenuation correction (AC) of the nuclear projection data and optimized Wiener filtering of the SPECT reconstruction for improved image accuracy. Finally, simultaneous dual-imaging of a nude mouse was performed to demonstrated the utility of co-registration for accurate localization of a radioactive source.
单光子发射计算机断层扫描（SPECT）可以提供特定的功能信息，而磁共振成像（MRI）可以提供高空间分辨率的解剖信息以及互补的功能信息。在这项研究中，我们利用一种双模态 SPECT/MRI（MRSPECT）系统来研究 SPECT 和 MRI 的融合，以提高图像的准确性。MRSPECT 系统由碲化镉锌（CZT）核辐射探测器组成，与专门的射频（RF）线圈接口，该线圈放置在全身 4T MRI 系统中。演示了对非均匀探测器灵敏度和洛伦兹力效应进行适当校正的重要性。利用 MRI 数据对核投影数据进行衰减校正（AC），并对 SPECT 重建进行优化的维纳滤波，以提高图像的准确性。最后，对裸鼠进行了同时的双成像，以证明配准用于准确定位放射性源的实用性。
