Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, Mexico.
Peptides. 2011 Dec;32(12):2400-6. doi: 10.1016/j.peptides.2011.09.018. Epub 2011 Sep 28.
Folic acid is antidepressant, either alone or combined with several antidepressant drugs. However, the antidepressant-like actions of folic acid combined with intra-lateral septal (LSN) infusions of neuropeptide Y (NPY) in the forced swimming test (FST) have not been tested before. Thus, systemic injections of fluoxetine (20.0mg/kg, P<0.05; s.c.) or 17-β estradiol (10.0 μg/rat, P<0.05; s.c.) or oral administrations of folic acid (50.0 mg/kg, P<0.05; 75.0 mg/kg, P<0.05) or NPY intra-LSN (3.0 μg, P<0.05; 3.5 μg, P<0.05) reduced immobility of ovariectomized Wistar rats. Subthreshold doses of: folic acid (25.0 mg/kg) or 17-β estradiol (5.0 μg/rat, P<0.05) or fluoxetine (15.0 mg/kg, P<0.05; s.c.) combined with subthreshold doses of NPY (2.5 μg/rat, P<0.05; intra-LSN) and these combinations produced antidepressant-like actions; which were canceled by BIBP 3226 (a NPY-Y1 receptor antagonist). It is concluded that folic acid produced antidepressant-like effects probably through the participation of the NPY Y1 receptors found in the lateral septal nuclei.
叶酸具有抗抑郁作用，无论是单独使用还是与几种抗抑郁药物联合使用。然而，在强迫游泳试验（FST）中，叶酸与内侧隔核（LSN）内神经肽 Y（NPY）联合输注的抗抑郁样作用尚未得到测试。因此，系统注射氟西汀（20.0mg/kg，P<0.05；皮下注射）或 17-β 雌二醇（10.0 μg/大鼠，P<0.05；皮下注射）或口服叶酸（50.0mg/kg，P<0.05；75.0mg/kg，P<0.05）或 NPY 内 LSN（3.0μg，P<0.05；3.5μg，P<0.05）可减少去卵巢 Wistar 大鼠的不动性。亚阈剂量的：叶酸（25.0mg/kg）或 17-β 雌二醇（5.0μg/大鼠，P<0.05）或氟西汀（15.0mg/kg，P<0.05；皮下注射）与亚阈剂量的 NPY（2.5μg/大鼠，P<0.05；内 LSN）联合使用可产生抗抑郁样作用；这些组合通过 BIBP 3226（一种 NPY-Y1 受体拮抗剂）被取消。结论是，叶酸产生抗抑郁样作用可能是通过参与外侧隔核中的 NPY Y1 受体。
