Molina-Hernández Miguel, Téllez-Alcántara N Patricia, Olivera-López Jorge I, Jaramillo M Teresa
Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México,
Psychopharmacology (Berl). 2014 Sep;231(17):3343-50. doi: 10.1007/s00213-013-3251-1. Epub 2013 Aug 24.
There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects.
We examined the relationship between 17β-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST).
Topiramate was administered alone or combined with 17β-estradiol to ovariectomized rats submitted to the FST.
Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17β-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17β-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17β-estradiol (P < 0.05) reduced locomotion.
Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.
抗抑郁药物的临床反应存在显著延迟，且抗抑郁治疗会产生副作用。
我们研究了在接受强迫游泳试验（FST）的去卵巢Wistar大鼠中，17β-雌二醇与托吡酯之间的关系。
将托吡酯单独或与17β-雌二醇联合给予接受FST的去卵巢大鼠。
托吡酯（20毫克/千克，P < 0.05；30毫克/千克，P < 0.05）通过增加游泳减少了不动时间；这些作用被非那雄胺（50毫克/千克）拮抗。在交互实验中，托吡酯（10毫克/千克）加17β-雌二醇（每只大鼠5微克；P < 0.05）通过增加游泳行为减少了不动时间。此外，17β-雌二醇（每只大鼠2.5微克）缩短了托吡酯抗抑郁样作用的起效时间（P < 0.05）。在旷场试验中，单独使用托吡酯或与17β-雌二醇联合使用（P < 0.05）均减少了运动。
单独使用托吡酯或与17β-雌二醇联合使用均产生抗抑郁样作用；且17β-雌二醇缩短了托吡酯抗抑郁样作用的起效时间。
