Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria de Lugo, Universidad de Santiago de Compostela, Lugo, Spain.
J Alzheimers Dis. 2012;28(2):291-6. doi: 10.3233/JAD-2011-110905.
The canine cognitive dysfunction syndrome (CDS) has been identified as a natural model for Alzheimer's disease (AD). We have used unbiased stereology to estimate the total number of basal forebrain cholinergic neurons expressing the nerve growth factor p75(NTR) receptor in young, aged cognitively-unimpaired (CU) and aged cognitively-impaired (CI) dogs. Aged-CI dogs showed a ∼20% decrement (p = 0.009) in p75(NTR) neurons compared to both the young and the aged-CU animals. These results suggest that the basal forebrain cholinergic system is affected in dogs with CDS and provide additional support for the use this canine syndrome as a model for AD research.
犬认知功能障碍综合征（CDS）已被确定为阿尔茨海默病（AD）的自然模型。我们使用无偏立体学方法来估计表达神经生长因子 p75（NTR）受体的基底前脑胆碱能神经元的总数，这些犬来自年轻、认知正常（CU）的老年犬和认知受损（CI）的老年犬。与年轻组和认知正常的老年组相比，认知受损的老年犬的 p75（NTR）神经元减少了约 20%（p = 0.009）。这些结果表明，CDS 犬的基底前脑胆碱能系统受到了影响，并为使用这种犬综合征作为 AD 研究模型提供了额外的支持。
