MRC Toxicology Unit, Leicester, UK.
Biochem Biophys Res Commun. 2011 Oct 28;414(3):445-50. doi: 10.1016/j.bbrc.2011.09.110. Epub 2011 Sep 28.
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, Brenner and Horvitz. Since then it has been clear that alteration of apoptotic pathways is a common feature of tumors, enabling cancer cells to survive chemotherapeutic interventions. Thus, apoptosis is an attractive target in cancer therapy, with the aim to revert the cancer-related alterations of the cell death machinery. Here, we overview the fundamental apoptotic pathways and summarize the attempts to target apoptosis to restore cell death in cancer cells with a special focus on the p53-family and autophagy.
程序性细胞死亡是一项重大发现，其发现者苏尔斯顿、布伦纳和霍维茨于 2002 年获得诺贝尔生理学或医学奖。此后人们已经清楚地认识到，凋亡途径的改变是肿瘤的一个常见特征，使癌细胞能够在化疗干预下存活。因此，凋亡是癌症治疗的一个有吸引力的靶点，目的是使与癌症相关的细胞死亡机制的改变恢复正常。在这里，我们概述了基本的凋亡途径，并总结了试图靶向凋亡以恢复癌细胞死亡的尝试，特别关注了 p53 家族和自噬。
