相似文献
1
Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.
Genes Cancer. 2013 Sep;4(9-10):334-41. doi: 10.1177/1947601913485415.
2
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.
Mol Cell Biol. 2001 Jul;21(14):4713-24. doi: 10.1128/MCB.21.14.4713-4724.2001.
3
Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states.
Biochim Biophys Acta. 2016 Sep;1862(9):1581-6. doi: 10.1016/j.bbadis.2016.05.022. Epub 2016 May 31.
4
Mixed-lineage kinase control of JNK and p38 MAPK pathways.
Nat Rev Mol Cell Biol. 2002 Sep;3(9):663-72. doi: 10.1038/nrm906.
5
MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase.
J Biol Chem. 1997 Jun 13;272(24):15167-73. doi: 10.1074/jbc.272.24.15167.
6
Expression and function of mixed lineage kinases in dendritic cells.
Int Immunol. 2007 Aug;19(8):923-33. doi: 10.1093/intimm/dxm050. Epub 2007 Aug 13.
7
Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Brain Res. 2004 Apr 2;1003(1-2):86-97. doi: 10.1016/j.brainres.2003.11.073.
8
Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
Int J Exp Pathol. 2007 Apr;88(2):111-26. doi: 10.1111/j.1365-2613.2007.00531.x.
9
Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.
J Biochem. 2001 Dec;130(6):773-81. doi: 10.1093/oxfordjournals.jbchem.a003048.
10
Mixed lineage kinase-4 promotes gastric carcinoma tumorigenesis through suppression of the c-Jun N-terminal kinase signaling pathway.
Exp Ther Med. 2018 Oct;16(4):3317-3324. doi: 10.3892/etm.2018.6618. Epub 2018 Aug 20.
引用本文的文献
1
Mixed lineage kinase (MLK) controls tumor development and angiogenesis.
Angiogenesis. 2025 May 2;28(3):29. doi: 10.1007/s10456-025-09978-4.
2
MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway.
Oncogene. 2024 Jul;43(30):2307-2324. doi: 10.1038/s41388-024-03055-8. Epub 2024 Jun 10.
3
TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer.
Oncogene. 2023 Mar;42(14):1132-1143. doi: 10.1038/s41388-023-02633-6. Epub 2023 Feb 22.
4
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy.
MedComm (2020). 2022 Nov 3;3(4):e175. doi: 10.1002/mco2.175. eCollection 2022 Dec.
5
Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer.
Genes (Basel). 2022 Oct 3;13(10):1786. doi: 10.3390/genes13101786.
6
Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2 breast cancer by ceramide-loaded nanoparticles.
Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2205454119. doi: 10.1073/pnas.2205454119. Epub 2022 Sep 12.
7
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.
Oncogene. 2021 Oct;40(43):6153-6165. doi: 10.1038/s41388-021-02007-w. Epub 2021 Sep 13.
8
Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.
Cancer Lett. 2021 Sep 1;515:1-13. doi: 10.1016/j.canlet.2021.04.015. Epub 2021 May 27.
9
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7961-7970. doi: 10.1073/pnas.1921325117. Epub 2020 Mar 24.
10
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.
Mol Cancer. 2020 Jan 28;19(1):17. doi: 10.1186/s12943-019-1120-1.
本文引用的文献
1
MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.
Cancer Res. 2012 Aug 15;72(16):4130-40. doi: 10.1158/0008-5472.CAN-12-0655. Epub 2012 Jun 13.
2
Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells.
Exp Cell Res. 2012 Aug 15;318(14):1641-8. doi: 10.1016/j.yexcr.2012.05.002. Epub 2012 May 28.
3
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8149-54. doi: 10.1073/pnas.1200804109. Epub 2012 May 7.
4
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.
Oncogene. 2012 Aug 23;31(34):3889-900. doi: 10.1038/onc.2011.544. Epub 2011 Dec 5.
5
Cell death pathology: the war against cancer.
Biochem Biophys Res Commun. 2011 Oct 28;414(3):445-50. doi: 10.1016/j.bbrc.2011.09.110. Epub 2011 Sep 28.
6
Mixed lineage kinase 3 modulates β-catenin signaling in cancer cells.
J Biol Chem. 2011 Oct 28;286(43):37470-82. doi: 10.1074/jbc.M111.298943. Epub 2011 Aug 31.
7
Systems biology analysis of programmed cell death.
Trends Biochem Sci. 2010 Oct;35(10):556-64. doi: 10.1016/j.tibs.2010.04.008. Epub 2010 May 28.
8
MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.
Oncogene. 2010 Aug 5;29(31):4399-411. doi: 10.1038/onc.2010.198. Epub 2010 May 31.
9
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
J Biol Chem. 2010 Jul 16;285(29):22426-36. doi: 10.1074/jbc.M110.123786. Epub 2010 Apr 26.
10
Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation.
Mol Endocrinol. 2010 Mar;24(3):598-607. doi: 10.1210/me.2009-0387. Epub 2010 Feb 11.
Zotero 插件