Internal Medicine, Soonchunhyang University Cheonan Hospital, Republic of Korea.
Clin Toxicol (Phila). 2011 Nov;49(9):815-9. doi: 10.3109/15563650.2011.614248. Epub 2011 Oct 5.
The human toxicity of synthetic auxin analogue herbicides has not been extensively studied.
Clinical outcome was assessed from medical records of 17 patients who had intentionally ingested auxin pesticides with active ingredients like dicamba, triclopyr, MCPA or mecoprop. The patients were interviewed after discharge to follow outcome (interval 2 to 56 months).
One patient who had ingested 500 mL of a mecoprop product died of hypotension and respiratory failure 36 hours after hospital admission. The other 16 patients recovered and were discharged by hospital day 28. After discharge, four patients died from causes not related to herbicide intoxication. In the 12 surviving patients, no long-term effects were reported.
Human toxicity of synthetic auxins appears relatively benign with conservative treatment. However, when the amount ingested is above several hundred milliliters of commercial product, especially in combination of mecoprop with other intoxicants (e.g. alcohol), shock with respiratory failure may develop and lead to death.
合成生长素类似物除草剂的人体毒性尚未得到广泛研究。
对 17 名故意摄入含有二甲四氯、三氯吡氧乙酸、MCPA 或麦草畏等活性成分的生长素农药的患者的医疗记录进行了临床结局评估。出院后对患者进行了随访（间隔 2 至 56 个月）以了解结局。
1 名摄入了 500 毫升麦草畏产品的患者在入院后 36 小时因低血压和呼吸衰竭死亡。其他 16 名患者在住院第 28 天康复出院。出院后，有 4 名患者死于与除草剂中毒无关的原因。在 12 名幸存患者中，未报告出现长期影响。
保守治疗时，合成生长素的人体毒性似乎相对良性。然而，当摄入的量超过几百毫升商业产品时，特别是麦草畏与其他毒物（如酒精）同时摄入时，可能会出现休克伴呼吸衰竭，导致死亡。
