Health Protection Agency Microbiology Services-Newcastle Laboratory, Specialist Virology Centre, Newcastle, UK.
Expert Rev Anti Infect Ther. 2011 Oct;9(10):891-9. doi: 10.1586/eri.11.105.
Hepatitis B virus (HBV) is a partially double stranded DNA virus that can integrate into host cell chromosomes as covalently closed circular DNA forms. HBV reactivation following hematopoietic stem cell transplantation in recipients with evidence of past HBV exposure, as well as exacerbation of a current HBV infection in HBV carrier recipients, secondary to chemotherapy and post-transplant immunosuppression that affect both humoral and cell-mediated control of HBV infection, are well documented in the literature. Management options include HBV-DNA screening and antiviral prophylaxis. Nucleos(t)ide analogues have been used at the start of chemotherapy and pretransplantation, with the course continuing for 6 months. However, depending on the serum HBV-DNA level, the antiviral agent might be given until a therapeutic end point is reached.
乙型肝炎病毒（HBV）是一种部分双链 DNA 病毒，可整合到宿主细胞染色体中，形成共价闭合环状 DNA 形式。在有 HBV 暴露史的受者中，造血干细胞移植后 HBV 再激活，以及 HBV 携带者受者中 HBV 感染恶化，继发于化疗和移植后免疫抑制，这两种情况均会影响 HBV 感染的体液和细胞介导控制，在文献中已有充分记载。管理选择包括 HBV-DNA 筛查和抗病毒预防。核苷（酸）类似物在化疗开始时和移植前使用，疗程持续 6 个月。然而，根据血清 HBV-DNA 水平，可能会给予抗病毒药物，直到达到治疗终点。
