Roelofse J A, van der Bijl P, Stegmann D H, Hartshorne J E
Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
J Oral Maxillofac Surg. 1990 Aug;48(8):791-7; discussion 797. doi: 10.1016/0278-2391(90)90333-w.
Three different dosages (0.25, 0.35, and 0.45 mg/kg) of rectally administered midazolam were compared with each other and with placebo for preanesthetic medication in children undergoing dental extractions. Eighty patients between the ages of 2 and 10 years were randomly allocated into four groups in this double-blind study. The results from this trial show that 30 minutes after rectal administration of all doses of midazolam, good anxiolysis, sedation, and cooperation were obtained in most patients. A high prevalence (23%) of disinhibition reactions was observed, particularly in the 0.45 mg/kg group. For this reason, 0.25 or 0.35 mg/kg appears to be the dose of choice when rectal midazolam is used for premedication in children.
将三种不同剂量（0.25、0.35和0.45毫克/千克）经直肠给予的咪达唑仑相互比较，并与安慰剂比较，用于接受拔牙手术儿童的麻醉前用药。在这项双盲研究中，80名年龄在2至10岁之间的患者被随机分为四组。该试验结果表明，在经直肠给予所有剂量咪达唑仑30分钟后，大多数患者获得了良好的抗焦虑、镇静和合作效果。观察到脱抑制反应的发生率较高（23%），尤其是在0.45毫克/千克组。因此，当直肠给予咪达唑仑用于儿童术前用药时，0.25或0.35毫克/千克似乎是首选剂量。
