Roelofse J A, de V Joubert J J
Faculty of Dentistry, University of Stellenbosch, Cape Town, Republic of South Africa.
Anesth Prog. 1990 Nov-Dec;37(6):286-9.
Eighty healthy children, between the ages of 2 and 7 years, undergoing dental procedures were monitored with a pulse oximeter for changes in arterial oxygen saturation. The children were randomly allocated into 4 groups in this double-blind study. Three groups received rectal midazolam, and the other group a placebo (saline) as premedication 30 min prior to induction of anesthesia. Group A children received midazolam 0.25 mg/kg, Group B 0.35 mg/kg and Group C 0.45 mg/kg. The results from this trial show no statistical significant difference between the treatment groups as to the effect on either systolic or diastolic blood pressure, respiration, or pulse rates at either pre- or post-sedation levels. However, the oxygen saturation levels for groups B and C differed significantly from those of the placebo groups 30 minutes after premedication (P = 0.0259).
八十名年龄在2至7岁之间、正在接受牙科治疗的健康儿童，使用脉搏血氧仪监测动脉血氧饱和度的变化。在这项双盲研究中，这些儿童被随机分为4组。三组接受直肠注射咪达唑仑，另一组接受安慰剂（生理盐水）作为麻醉诱导前30分钟的术前用药。A组儿童接受0.25毫克/千克的咪达唑仑，B组接受0.35毫克/千克，C组接受0.45毫克/千克。该试验结果表明，在镇静前或镇静后水平，各治疗组在对收缩压、舒张压、呼吸或脉搏率的影响方面没有统计学上的显著差异。然而，在术前用药30分钟后，B组和C组的血氧饱和度水平与安慰剂组有显著差异（P = 0.0259）。
