用于 GM1 神经节苷脂贮积病相关β-半乳糖苷酶的荧光探针：N-(丹磺酰氨基)己基氨甲酰基戊基-1,5-二脱氧-1,5-亚氨基-D-半乳糖醇。
A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.
机构信息
Carbohydrate Chemistry Team, Industrial Research Limited, PO Box 31-310, 5040 Lower Hutt, New Zealand.
出版信息
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6872-5. doi: 10.1016/j.bmcl.2011.09.012. Epub 2011 Sep 10.
PMID:21974950
Abstract
N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant β-gal as well as aberrant GM1 gangliosides by live cell imaging.
摘要
N-(丹磺酰氨基)己基氨甲酰基戊基-1,5-二脱氧-1,5-亚氨基-D-半乳糖醇，一种β-半乳糖苷酶的强竞争性抑制剂，可增强成纤维细胞中残余β-半乳糖苷酶的活性，并作为追踪突变β-半乳糖和异常 GM1 神经节苷脂命运的诊断化合物的先导。
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