Department of Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska St, 0-776 Warsaw, Poland.
J Cell Biochem. 2012 Feb;113(2):426-32. doi: 10.1002/jcb.23393.
The electrolyte transport system across human airway epithelium followed by water movement is essential for the normal mucociliary clearance that allows the maintenance of the aseptic condition of the respiratory tract. The function of epithelial cells is to control and regulate ionic composition and volume of fluids in the airways. Various types of proteins taking part in assuring effective ions and water transport in apical and basolateral membranes of the airway epithelium have been found (e.g., CFTR, ENaC, CaCC, ORCC, potassium channels, NaKATPase, aquaporins). The paper reviews the current state of the art in the field of ion channels, transporters, and other signaling proteins identified in the human bronchial epithelium.
人呼吸道上皮的电解质转运系统及其伴随的水运动对于正常的黏液纤毛清除功能至关重要，后者可维持呼吸道的无菌状态。上皮细胞的功能是控制和调节气道中液体的离子组成和容量。已发现多种参与保证气道上皮细胞顶膜和基底外侧膜中有效离子和水转运的蛋白质（例如 CFTR、ENaC、CaCC、ORCC、钾通道、NaKATPase、水通道蛋白）。本文综述了在人类支气管上皮细胞中鉴定出的离子通道、转运蛋白和其他信号蛋白领域的最新研究进展。
