Yuan Zuoqing, Zhao Bosheng, Zhang Yu
School of Life Sciences, Shandong University of Technology, Zibo, People's Republic of China.
Toxicol Ind Health. 2012 Jun;28(5):449-57. doi: 10.1177/0748233711414609. Epub 2011 Oct 5.
In this study, the toxicity, behavioral and antioxidant activity effects of dimethylsulfoxide (DMSO) on planarian Dugesia japonica were investigated. The results showed that the mortality was directly proportional to the DMSO concentration, and planarian locomotor velocity decreased as the concentration of DMSO increased. The recovery of the motility for planarians pre-exposed to DMSO was found to be time- and dose-dependent, and only those pre-exposed to 0.1-3% DMSO resulted in full recovery. The antioxidant enzymes of planarians in response to long-term DMSO stress was also altered in a time- and dose-dependent manner. Planarians revealed more tolerance to DMSO toxicity at low DMSO (0.1%) level in short- and long-term DMSO stress, in which an efficient antioxidant system was involved and the motility was not affected.
本研究考察了二甲基亚砜（DMSO）对日本三角涡虫的毒性、行为及抗氧化活性影响。结果表明，死亡率与DMSO浓度成正比，且随着DMSO浓度增加，三角涡虫的运动速度降低。发现预先暴露于DMSO的三角涡虫运动能力的恢复具有时间和剂量依赖性，只有预先暴露于0.1 - 3% DMSO的三角涡虫才能完全恢复。长期DMSO胁迫下三角涡虫的抗氧化酶也呈时间和剂量依赖性变化。在短期和长期DMSO胁迫下，三角涡虫在低DMSO（0.1%）水平对DMSO毒性表现出更高耐受性，其中涉及高效的抗氧化系统且运动能力未受影响。
