埃及伊蚊对马亚罗病毒的实验性传播。
Experimental transmission of Mayaro virus by Aedes aegypti.
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
出版信息
Am J Trop Med Hyg. 2011 Oct;85(4):750-7. doi: 10.4269/ajtmh.2011.11-0359.
Abstract
Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log(10) and 7.3 log(10) plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log(10) PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.
摘要
马雅罗热疫情与南美洲马雅罗病毒（MAYV）的森林传播周期有关。为了评估普通城市蚊子传播 MAYV 的潜力，对来自秘鲁伊基托斯的埃及伊蚊进行了实验室媒介效能研究。埃及伊蚊的经口感染率为 0%（0/31）至 84%（31/37），血餐病毒滴度在 3.4 log(10) 和 7.3 log(10)噬菌斑形成单位（PFU）/mL 之间。通过唾液采集和暴露于幼鼠，显示出 70%（21/30）感染蚊子传播 MAYV。通过实时聚合酶链反应确定发热患者体内的病毒 RNA 量，范围从 2.7 到 5.3 log(10)PFU 当量/mL。在人类病毒血症中遇到的 MAYV 滴度下，埃及伊蚊的口服易感性可能限制了启动城市传播周期的机会；然而，埃及伊蚊传播 MAYV 表明了该物种的媒介效能，并提示了城市传播的潜力。
相似文献
1
Experimental transmission of Mayaro virus by Aedes aegypti.埃及伊蚊对马亚罗病毒的实验性传播。
Am J Trop Med Hyg. 2011 Oct;85(4):750-7. doi: 10.4269/ajtmh.2011.11-0359.
2
Transmission potential of Mayaro virus in Florida Aedes aegypti and Aedes albopictus mosquitoes.马亚罗病毒在佛罗里达州埃及伊蚊和白纹伊蚊中的传播潜力
Med Vet Entomol. 2018 Dec;32(4):436-442. doi: 10.1111/mve.12322. Epub 2018 Jul 13.
3
Vector competence of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquitoes for Mayaro virus.埃及伊蚊、白纹伊蚊和致倦库蚊对马亚罗病毒的媒介效能。
PLoS Negl Trop Dis. 2020 Apr 14;14(4):e0007518. doi: 10.1371/journal.pntd.0007518. eCollection 2020 Apr.
4
Assessment of Mayaro virus vector competence of the mosquito Aedes aegypti (Linnaeus, 1762) populations in Argentine using dose-response assays.利用剂量反应试验评估阿根廷埃及伊蚊（Linnaeus，1762）种群对马亚罗病毒的媒介效能。
Med Vet Entomol. 2024 Jun;38(2):234-243. doi: 10.1111/mve.12712. Epub 2024 Mar 15.
5
Differential Susceptibility of Aedes aegypti and Aedes albopictus Mosquitoes to Infection by Mayaro Virus Strains.埃及伊蚊和白纹伊蚊对马雅罗病毒株感染的差异易感性。
Am J Trop Med Hyg. 2023 May 30;109(1):115-122. doi: 10.4269/ajtmh.22-0777. Print 2023 Jul 5.
6
Infection Pattern of Mayaro Virus in Aedes aegypti (Diptera: Culicidae) and Transmission Potential of the Virus in Mixed Infections With Chikungunya Virus.埃及伊蚊中马亚罗病毒的感染模式及与基孔肯雅病毒混合感染时病毒的传播潜力。
J Med Entomol. 2019 Apr 16;56(3):832-843. doi: 10.1093/jme/tjy241.
7
Dynamic of Mayaro Virus Transmission in , Mosquitoes, and a Mice Model.中美洲地区梅萨罗病毒传播的动态：蚊子和小鼠模型。
Viruses. 2023 Mar 21;15(3):799. doi: 10.3390/v15030799.
8
The RNAi Pathway Is Important to Control Mayaro Virus Infection in but not for -Mediated Protection.RNAi 通路对控制梅奥罗病毒感染很重要，但对 -Mediated 保护则不重要。
Viruses. 2020 Aug 10;12(8):871. doi: 10.3390/v12080871.
9
Mayaro virus, a potential threat for Europe: vector competence of autochthonous vector species.马亚罗病毒，对欧洲的潜在威胁：本地媒介物种的媒介效能。
Parasit Vectors. 2024 May 4;17(1):200. doi: 10.1186/s13071-024-06293-7.
10
Differential Susceptibility and Innate Immune Response of and to the Haitian Strain of the Mayaro Virus.登革热病毒海地株对 和 的差异易感性及固有免疫应答。
Viruses. 2019 Oct 9;11(10):924. doi: 10.3390/v11100924.
引用本文的文献
1
A comprehensive murine clinical model for development of countermeasures and studying Mayaro virus infection.一种用于开发应对措施和研究马亚罗病毒感染的综合性小鼠临床模型。
PLoS Negl Trop Dis. 2025 Jul 31;19(7):e0013333. doi: 10.1371/journal.pntd.0013333. eCollection 2025 Jul.
2
Effect of prolonged dehydration stress on the vector competence of for Mayaro virus.长期脱水应激对马亚罗病毒传播媒介能力的影响。
bioRxiv. 2025 Jun 16:2025.06.16.660000. doi: 10.1101/2025.06.16.660000.
3
(Re)Emerging Arboviruses of Public Health Significance in the Brazilian Amazon.巴西亚马逊地区具有公共卫生意义的（再）新兴虫媒病毒
Microorganisms. 2025 Mar 12;13(3):650. doi: 10.3390/microorganisms13030650.
4
Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies.甲病毒非结构蛋白2：病毒复制的多功能调节因子及抗甲病毒疗法的潜在靶点
Rev Med Virol. 2025 Mar;35(2):e70030. doi: 10.1002/rmv.70030.
5
Effect of chikungunya, Mayaro and Una virus coinfection on vector competence of mosquitoes.基孔肯雅病毒、马亚罗病毒和乌纳病毒共感染对蚊子媒介能力的影响。
One Health. 2025 Feb 7;20:100991. doi: 10.1016/j.onehlt.2025.100991. eCollection 2025 Jun.
6
Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures.旧大陆甲病毒的神经发病机制：医学应对措施研发的考量因素
Viruses. 2025 Feb 14;17(2):261. doi: 10.3390/v17020261.
7
In Vitro Evaluation of the Antiviral Activity of Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) Against Mayaro Virus.表没食子儿茶素-3-没食子酸酯（EGCG）对马亚罗病毒抗病毒活性的体外评价
Viruses. 2025 Feb 14;17(2):258. doi: 10.3390/v17020258.
8
Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein.具有免疫原性的重组马亚罗病毒样颗粒呈现天然组装的糖蛋白。
NPJ Vaccines. 2024 Dec 17;9(1):243. doi: 10.1038/s41541-024-01021-9.
9
Excellent capability for molecular detection of -borne dengue, Zika, and chikungunya viruses but with a need for increased capacity for yellow fever and Japanese encephalitis viruses: an external quality assessment in 36 European laboratories.在检测蚊媒传播的登革热、寨卡和基孔肯雅病毒方面具备出色的分子检测能力，但在黄热病和日本脑炎病毒检测能力方面有待提高：36家欧洲实验室的外部质量评估
J Clin Microbiol. 2025 Jan 31;63(1):e0091024. doi: 10.1128/jcm.00910-24. Epub 2024 Dec 16.
10
Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti.暂时的沃尔巴克氏体感染对埃及伊蚊中甲病毒的影响具有可变性。
PLoS Negl Trop Dis. 2024 Nov 4;18(11):e0012633. doi: 10.1371/journal.pntd.0012633. eCollection 2024 Nov.
本文引用的文献
1
Arboviral etiologies of acute febrile illnesses in Western South America, 2000-2007.2000-2007 年南美洲西部急性发热疾病的虫媒病毒病因。
PLoS Negl Trop Dis. 2010 Aug 10;4(8):e787. doi: 10.1371/journal.pntd.0000787.
2
Imported Mayaro virus infection in the Netherlands.输入性马亚罗病毒感染在荷兰。
J Infect. 2010 Oct;61(4):343-5. doi: 10.1016/j.jinf.2010.06.009. Epub 2010 Jun 19.
3
Infection with Mayaro virus in a French traveller returning from the Amazon region, Brazil, January, 2010.2010 年 1 月，一名从巴西亚马逊地区返回的法国旅行者感染马亚罗病毒。
Euro Surveill. 2010 May 6;15(18):19563.
4
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission.秘鲁伊基托斯 1999 年至 2005 年登革热病毒的流行病学：传播的间隔期和流行期模式。
PLoS Negl Trop Dis. 2010 May 4;4(5):e670. doi: 10.1371/journal.pntd.0000670.
5
Assessing yellow Fever risk in the ecuadorian Amazon.评估厄瓜多尔亚马逊地区的黄热病风险。
J Glob Infect Dis. 2009 Jan;1(1):7-13. doi: 10.4103/0974-777X.49188.
6
Present and future arboviral threats.当前和未来的虫媒病毒威胁。
Antiviral Res. 2010 Feb;85(2):328-45. doi: 10.1016/j.antiviral.2009.10.008. Epub 2009 Oct 24.
7
Venezuelan equine encephalitis virus in Iquitos, Peru: urban transmission of a sylvatic strain.秘鲁伊基托斯的委内瑞拉马脑炎病毒：丛林株的城市传播。
PLoS Negl Trop Dis. 2008;2(12):e349. doi: 10.1371/journal.pntd.0000349. Epub 2008 Dec 16.
8
A single mutation in chikungunya virus affects vector specificity and epidemic potential.基孔肯雅病毒的一个单一突变会影响载体特异性和流行潜力。
PLoS Pathog. 2007 Dec;3(12):e201. doi: 10.1371/journal.ppat.0030201.
9
Mosquitoes inoculate high doses of West Nile virus as they probe and feed on live hosts.蚊子在刺探并吸食活体宿主时会接种高剂量的西尼罗河病毒。
PLoS Pathog. 2007 Sep 14;3(9):1262-70. doi: 10.1371/journal.ppat.0030132.
10
Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus.基孔肯雅病毒的变化模式：一种人畜共患虫媒病毒的再度出现。
J Gen Virol. 2007 Sep;88(Pt 9):2363-2377. doi: 10.1099/vir.0.82858-0.
Zotero 插件