Lands W E
Annu Rev Physiol. 1979;41:633-52. doi: 10.1146/annurev.ph.41.030179.003221.
With improved techniques for isolation and identification of materials, thromboxane (TXA2) and prostacyclin (PGI2) derivatives are now recognized as more abundant in some tissues and more potent than PGE2 and PGF2alpha. The rapid appearance and disappearance of these autacoids can be regulated at many points along the enzymatic path. Two important features affecting the rate of overall prostaglandin formation are the availability of non-esterified substrate and the availability of hydroperoxide activator for the cyclooxygenase. The fate of the endoperoxide formed by this reaction then depends upon the different relative amounts of the synthases and dehydrogenases in each type of synthesizing cell. Important future developments will indicate ways in which the amounts of these enzyme activities are altered and the ways in which the prostaglandin receptors interact with cellular adenyl cyclase and adrenergic receptors.
随着材料分离和鉴定技术的改进，血栓素（TXA2）和前列环素（PGI2）衍生物现在被认为在某些组织中含量更丰富，且比前列腺素E2和前列腺素F2α更具效力。这些自分泌物质的快速出现和消失可以在酶促途径的多个环节进行调节。影响前列腺素总体形成速率的两个重要因素是非酯化底物的可用性和环氧化酶的氢过氧化物激活剂的可用性。该反应形成的内过氧化物的命运则取决于每种合成细胞中合酶和脱氢酶的不同相对含量。未来重要的发展将指明改变这些酶活性量的方法，以及前列腺素受体与细胞腺苷酸环化酶和肾上腺素能受体相互作用的方式。
