Vyas Himesh V, Eidem Benjamin W, Cetta Frank, Acharya Ganesh, Huhta James, Roberson David, Cuneo Bettina
Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Ann Pediatr Cardiol. 2011 Jul;4(2):129-34. doi: 10.4103/0974-2069.84650.
Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated.
To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome (HLHS) to those of normal fetuses (matched for gestational age.)
Cross-sectional retrospective study conducted at 2 large perinatal centers (2003-2007). Fetuses with HLHS (n = 13) were compared with normal fetuses (n = 207) in 5 gestational age groups. TDI data included peak systolic (s'), peak early (e'), and late diastolic velocities (a'). Linear regression was used to compare TDI parameters in fetuses with HLHS to normal fetuses matched for gestational age.
Fetuses with HLHS had significantly reduced lateral tricuspid annular e' as compared to normal fetuses. Both normal fetuses and those with HLHS had linear increase in TDI velocities with advancing gestational age.
TDI velocities are abnormal in fetuses with HLHS. TDI can be useful in serial follow-up of cardiac function in fetuses with HLHS.
组织多普勒成像（TDI）是心肌功能的敏感指标。其在胎儿中的作用尚未得到广泛评估。
比较左心发育不全综合征（HLHS）胎儿与正常胎儿（匹配孕周）的心肌组织多普勒速度。
在2个大型围产期中心进行横断面回顾性研究（2003 - 2007年）。将HLHS胎儿（n = 13）与5个孕周组的正常胎儿（n = 207）进行比较。TDI数据包括收缩期峰值（s'）、舒张早期峰值（e'）和舒张晚期速度（a'）。采用线性回归比较HLHS胎儿与匹配孕周的正常胎儿的TDI参数。
与正常胎儿相比，HLHS胎儿三尖瓣环外侧e'明显降低。正常胎儿和HLHS胎儿的TDI速度均随孕周增加呈线性增加。
HLHS胎儿的TDI速度异常。TDI可用于HLHS胎儿心功能的系列随访。
