Godoy Fúlvio B, Fonseca Belchiolina B, Levenhagen Marcelo A, Franco Mariane A, Melo Roberta T, Beletti Marcelo E
Medicine Department of University Presidente Antonio Carlos - UNIPAC.
J Cutan Aesthet Surg. 2011 May;4(2):105-10. doi: 10.4103/0974-2077.85025.
Hydrolipoclasy is an alternative technique less invasive than liposuction. Hydrolipoclasy uses normal saline or hypotonic solution and ultrasound waves that act directly on local adiposity. In the literature there are few reports of morphostructural changes on adipose tissue.
This study was aimed to evaluate the amount of fat cells injured immediately after treatment and after three days and also cell migration to the area treated using 8 pigs as experimental models, as well as cellular changes by transmission electron microscopy (TEM).
The Wilcoxon test was conducted, and a difference was found between the treated side and the corresponding control side on the number of viable cells. The treated side showed a smaller number of viable cells compared to the control side both immediately after treatment and 3 days later. Also occurring 3 days after treatment was the migration of lymphoid cells and fibroblasts, which shows the local inflammatory process and conjunctive neoformation. Soon after treatment there was fluid accumulation within adipocytes.
The results shown in this paper demonstrate Ultrasonic Hydrolipoclasy as a viable alternative for the treatment of localized fat deposits without the side effects of traditional surgical procedures. Better results are expected when hypotonic solution is used, since it penetrates into the cell.
水脂分解术是一种比抽脂术侵入性更小的替代技术。水脂分解术使用生理盐水或低渗溶液以及直接作用于局部脂肪的超声波。文献中关于脂肪组织形态结构变化的报道很少。
本研究旨在以8头猪为实验模型，评估治疗后即刻及三天后受损脂肪细胞的数量，以及细胞向治疗区域的迁移情况，并通过透射电子显微镜（TEM）观察细胞变化。
进行了威尔科克森检验，发现在活细胞数量上，治疗侧与相应对照侧之间存在差异。治疗后即刻及3天后，治疗侧的活细胞数量均少于对照侧。治疗3天后还出现了淋巴细胞和成纤维细胞的迁移，这表明存在局部炎症过程和结缔组织新生。治疗后不久，脂肪细胞内出现液体蓄积。
本文所示结果表明，超声水脂分解术是治疗局部脂肪堆积的一种可行替代方法，且无传统手术的副作用。使用低渗溶液时预期效果更佳，因为它能渗透到细胞内。
