• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

白喉-破伤风-无细胞百日咳与脊髓灰质炎灭活疫苗（Sabin株）联合疫苗诱导的脊髓灰质炎灭活疫苗（Sabin株）免疫原性

[Immunogenicity of sabin inactivated poliovirus vaccine induced by diphtheria-tetanus-acellular pertussis and Sabin inactivated poliovirus combined vaccine].

作者信息

Ma Yan, Qin Min, Hu Hui-Qiong, Ji Guang, Feng Ling, Gao Na, Gu Jie, Xie Bing-Feng, He Ji-Hong, Sun Ming-Bo

机构信息

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboraory of Vaccine Research & Development on Severe Infectious Diseases, Kunming 650118, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Jun;25(3):197-200.

PMID:21977591
Abstract

OBJECTIVE

In order to search the preparation process and optimazing dosage ratio of adsorbed diphtheria-tetanus-acellular pertussis and sabin inactivated poliovirus combined vaccine (DTaP-sIPV), the neutralizing antibody titers of IPV induced by different concentration of DTaP-sIPV were investigated on rats.

METHODS

Two batches of DTaP-sLPV were produced using different concentration of sIPV and the quality control was carried. Together with sabin-IPV and DTaP-wIPV ( boostrix-polio, GSK, Belgium) as control group, the DTaP-sIPV were administrated on three-dose schedule at 0, 1, 2 month on rats. Serum sample were collected 30 days after each dose and neutralizing antibody titers against three types poliovirus were determined using micro-neutralization test.

RESULTS

Two batches of prepared DTaP-sIPV and control sLPV were according to the requirement of Chinese Pharmacopoeia (Volume III, 2005 edition) and showed good stability. The seropositivity rates were 100% for sabin inactivated poliovirus antigen in all groups. The GMTs (Geometric mean titers) of neutralizing antibodies against three types poliovirus increased.

CONCLUSION

The prepared DTaP-sIPV was safe, stable and effective and could induced high level neutralizing antibody against poliovirus on rats.

摘要

目的

为探索吸附无细胞百白破与脊髓灰质炎灭活疫苗（DTaP-sIPV）的制备工艺及优化配比，在大鼠上研究不同浓度的DTaP-sIPV诱导的脊髓灰质炎病毒中和抗体效价。

方法

采用不同浓度的脊髓灰质炎灭活疫苗（sIPV）制备两批DTaP-sIPV并进行质量控制。将DTaP-sIPV与脊髓灰质炎减毒活疫苗（sabin-IPV）和吸附无细胞百白破与全细胞脊髓灰质炎联合疫苗（DTaP-wIPV，比利时葛兰素史克公司生产的百白破-脊髓灰质炎疫苗）作为对照组，于0、1、2月龄按三剂程序对大鼠进行接种。每次接种后30天采集血清样本，采用微量中和试验检测针对三种脊髓灰质炎病毒的中和抗体效价。

结果

制备的两批DTaP-sIPV及对照sIPV均符合《中国药典》（2005年版三部）要求，稳定性良好。所有组中脊髓灰质炎灭活疫苗抗原的血清阳转率均为100%。针对三种脊髓灰质炎病毒的中和抗体几何平均滴度（GMT）均升高。

结论

制备的DTaP-sIPV安全、稳定、有效，能在大鼠上诱导出高水平的针对脊髓灰质炎病毒的中和抗体。

相似文献

1
[Immunogenicity of sabin inactivated poliovirus vaccine induced by diphtheria-tetanus-acellular pertussis and Sabin inactivated poliovirus combined vaccine].白喉-破伤风-无细胞百日咳与脊髓灰质炎灭活疫苗（Sabin株）联合疫苗诱导的脊髓灰质炎灭活疫苗（Sabin株）免疫原性
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Jun;25(3):197-200.
2
Dynamic profiles of neutralizing antibody responses elicited in rhesus monkeys immunized with a combined tetravalent DTaP-Sabin IPV candidate vaccine.恒河猴接种联合四价 DTaP-Sabin 型脊髓灰质炎候选疫苗诱导的中和抗体反应的动态特征。
Vaccine. 2014 Feb 19;32(9):1100-6. doi: 10.1016/j.vaccine.2013.12.025. Epub 2014 Jan 7.
3
Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea.在韩国，一项比较联合使用无细胞百白破、灭活脊髓灰质炎（DTaP-IPV）疫苗与分别单独使用百白破（DTaP）和脊髓灰质炎（IPV）疫苗的免疫原性和安全性的随机对照研究：在婴儿中进行的研究。
Vaccine. 2011 Feb 11;29(8):1551-7. doi: 10.1016/j.vaccine.2010.12.094. Epub 2011 Jan 6.
4
Antibody responses of Macaca fascicularis against a new inactivated polio vaccine derived from Sabin strains (sIPV) in DTaP-sIPV vaccine.食蟹猴对DTaP-sIPV疫苗中一种源自萨宾株的新型灭活脊髓灰质炎疫苗（sIPV）的抗体反应。
Biologicals. 2013 May;41(3):184-9. doi: 10.1016/j.biologicals.2012.12.004. Epub 2013 Jan 30.
5
Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV).含 Sabin 株脊髓灰质炎灭活疫苗的白喉-破伤风-无细胞百日咳疫苗的 II 期和 III 期临床研究(DTaP-sIPV)。
J Infect Dis. 2013 Jul 15;208(2):275-83. doi: 10.1093/infdis/jit155. Epub 2013 Apr 8.
6
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine.一种青少年-成人剂型的吸附破伤风和白喉类毒素与无细胞百日咳疫苗联合制剂，在4至6岁儿童中与一种儿科剂型的无细胞百日咳疫苗及吸附白喉和破伤风类毒素与灭活脊髓灰质炎疫苗联合制剂相比，具有相当的免疫原性，但反应原性较低。
Vaccine. 2007 Jan 22;25(6):1121-5. doi: 10.1016/j.vaccine.2006.09.053. Epub 2006 Oct 2.
7
Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age.白喉-破伤风-无细胞百日咳疫苗和灭活脊髓灰质炎病毒疫苗，在4至6岁时单独或联合接种进行加强免疫。
Pediatr Infect Dis J. 2008 Apr;27(4):341-6. doi: 10.1097/INF.0b013e3181616180.
8
Immunogenicity and safety of a DTaP-IPV//PRP-T vaccine (Pentaxim) booster during the second year of life in Thai children primed with an acellular pertussis combined vaccine.在泰国儿童中，于生命第二年使用无细胞百日咳联合疫苗进行初免后，接种白百破-灭活脊髓灰质炎病毒疫苗//b型流感嗜血杆菌结合疫苗（百达生）加强针的免疫原性和安全性。
Southeast Asian J Trop Med Public Health. 2009 Mar;40(2):282-94.
9
One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine.全液体五组分无细胞百日咳、白喉、破伤风、灭活脊髓灰质炎、b型流感嗜血杆菌结合疫苗的一年期一级抗体持久性及加强免疫反应
Int J Infect Dis. 2007 Nov;11(6):488-95. doi: 10.1016/j.ijid.2007.01.006. Epub 2007 Mar 8.
10
New combination vaccines: DTaP-IPV (Kinrix) and DTaP-IPV/Hib (Pentacel).新联合疫苗：DTaP-IPV（金鑫宁）和 DTaP-IPV/Hib（沛儿）。
Ann Pharmacother. 2010 Mar;44(3):515-23. doi: 10.1345/aph.1M468.

引用本文的文献

1
Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic.带有T细胞表位的串联截短轮状病毒VP8*亚基蛋白作为非复制性肠胃外疫苗具有高度免疫原性。
Hum Vaccin Immunother. 2015;11(10):2483-9. doi: 10.1080/21645515.2015.1054583.
2
Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus ΔVP8* subunit parenteral vaccines.包含通用破伤风类毒素CD4(+) T细胞表位P2可显著增强重组轮状病毒ΔVP8*亚单位注射用疫苗的免疫原性。
Vaccine. 2014 Jul 31;32(35):4420-4427. doi: 10.1016/j.vaccine.2014.06.060. Epub 2014 Jun 21.
3
Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates.
构建并鉴定人轮状病毒重组 VP8*亚单位肠道外疫苗候选株。
Vaccine. 2012 Sep 21;30(43):6121-6. doi: 10.1016/j.vaccine.2012.07.078. Epub 2012 Aug 9.