Shanghai Research Center for Acupuncture and Meridians, Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China.
J Tradit Chin Med. 2011 Sep;31(3):256-62.
This article studied on five elements system and set general and strict model expectations combining with Traditional Chinese Medicine Zang-fu organs theory, in which absolute stable state, conditional stable state or transient stability and instability in mathematical models were corresponding to human healthy state, sub-healthy state (pathological plateau phase) and health deterioration state respectively. Model parameters were set up according to the mutual generation and restriction relations among five elements. The dynamic model of Five-Elements System was built, of which impulse responses were corresponding to human response under TCM treatment. Analyses of initial value and excitation response were conducted by numerical simulation and results turned out to meet the requirements of general model expectation: five elements system dynamic model had self-organization function; there existed only one non-global stable point and instability region in the five-dimensional space consisting of variables, in which instability was corresponding to pathological deterioration; system stable region was an unbounded domain and it included the stable sub-regions of special straight line-type, ray-type and line segment-type. Among those ray-types, some contained "Regression Peak" were classed as conditional stable regions while others as absolute ones. The existence of this peak indicates that our body must exceed a "Regression Threshold" when transiting from sub-healthy state (pathological plateau phase) to healthy state through self-regulation mechanism. Impulse excitation can reduce certain threshold and then increase the system health level, which is complied with the operating principle of Five-Elements System and the empirical rule of TCM clinical practice. This model has revealed qualitatively the inherent movement law of Five-Elements System and thus provides a new analysis tool for basic theoretical study on TCM.
本文运用五运六气理论,建立了五脏系统模型,通过设定一般性和严格性模型预期,结合五行生克制化关系确定模型参数,构建了五脏系统的动力学模型。数学模型中的绝对稳定态、条件稳定态或瞬态稳定与不稳定分别对应人体的健康态、亚健康态(病理平台期)和健康恶化态。利用数值模拟方法对模型的初值问题和脉冲响应进行了分析,结果符合一般性模型预期:五脏系统动力学模型具有自组织功能;在由变量构成的五维空间中,仅存在一个非全局稳定点和不稳定区域,不稳定对应于病理恶化;系统稳定区域是一个无界区域,它包含了特殊的直线型、射线型和线段型稳定子区域。在这些射线型中,一些包含“回归峰”的区域被归类为条件稳定区,而另一些则是绝对稳定区。该峰的存在表明,当身体通过自我调节机制从亚健康态(病理平台期)向健康态转变时,必须超过一个“回归阈值”。脉冲激励可以降低某些阈值,从而提高系统的健康水平,这符合五行系统的运行原理和中医临床实践的经验法则。该模型定性地揭示了五行系统的内在运动规律,为中医基础理论研究提供了新的分析工具。