吡格列酮添加治疗对二甲双胍和格列齐特控制 2 型糖尿病患者血糖的影响。
Effects of pioglitazone add-on to gliclazide and metformin on glycemic control in patients with type 2 diabetes.
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid , Jordan.
出版信息
Endocr Res. 2012;37(1):7-11. doi: 10.3109/07435800.2011.566238. Epub 2011 Oct 6.
OBJECTIVES
This study aims to evaluate the efficacy and safety of adding pioglitazone to treatment with metformin (MF) and gliclazide in patients with type 2 diabetes mellitus (DM2) who had inadequate glycemic control.
METHODS
This study is a retrospective cohort study based on King Abdullah University Hospital records concerning type 2 diabetic adult patients for year 2008. Patients included were assessed according to changes in glycosylated hemoglobin (HbA1c), lipid profile, albuminuria and liver enzymes before and after the addition of pioglitazone.
RESULTS
The patients included in the study had an initial mean HbA1c of 9.44%, which decreased to 7.56% after the addition of pioglitazone (P-value < 0.005).
目的
本研究旨在评估在二甲双胍（MF）和格列齐特治疗血糖控制不佳的 2 型糖尿病（DM2）患者中添加吡格列酮的疗效和安全性。
方法
本研究是基于 2008 年阿卜杜拉国王大学医院记录的 2 型糖尿病成年患者的回顾性队列研究。根据添加吡格列酮前后糖化血红蛋白（HbA1c）、血脂谱、白蛋白尿和肝酶的变化评估患者。
结果
研究纳入的患者初始平均 HbA1c 为 9.44%，添加吡格列酮后降至 7.56%（P 值 < 0.005）。
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