CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
Int J Pharm. 2011 Dec 12;421(1):130-4. doi: 10.1016/j.ijpharm.2011.09.030. Epub 2011 Sep 29.
Sodium Tripolyphosphate (STPP) is a food additive that is being used in the development of micro and nanoparticles as it induces ionic interactions with chitosan molecules. Although the ability of STPP to inhibit the growth of several food contaminants has been reported, studies on its activity against clinical isolates are scarce. Candida spp. are common causative agents of mucocutaneous infections including the vulvovaginal tegument and new therapeutic approaches are needed in order to treat resistant and recurrent cases. The aim of this study was to evaluate in vitro both antifungal (anti-Candida spp.) activity, and cytotoxicity, on human dermal fibroblasts, of STPP solutions. STPP showed an inhibitory species-dependent activity against several Candida spp. strains being particularly active on C. glabrata, followed by C. guilliermondii. In vitro, STPP showed a concentration dependent cytotoxicity. Therefore STPP use, in low concentrations, seems to be interesting in the development of drug delivery systems for the treatment of vulvovaginal candidosis.
三聚磷酸钠（STPP）是一种食品添加剂，由于其能与壳聚糖分子产生离子相互作用，因此被用于开发微纳米颗粒。尽管已有研究报道 STPP 能抑制多种食品污染物的生长，但对其抑制临床分离株活性的研究却很少。念珠菌属是引起黏膜皮肤感染的常见病原体，包括外阴阴道皮肤，需要新的治疗方法来治疗耐药和复发性病例。本研究旨在评估 STPP 溶液的体外抗真菌（抗念珠菌属）活性和对人真皮成纤维细胞的细胞毒性。STPP 对几种念珠菌属菌株表现出抑制物种依赖性的活性，对光滑念珠菌的活性特别强，其次是近平滑念珠菌。体外，STPP 表现出浓度依赖性细胞毒性。因此，在开发用于治疗外阴阴道念珠菌病的药物输送系统时，低浓度的 STPP 似乎很有前途。
