TRIM 蛋白与癌症。
TRIM proteins and cancer.
机构信息
Department of Biochemistry, Institute for Animal Experimentation, and Central Institute of Isotope Science, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.
出版信息
Nat Rev Cancer. 2011 Oct 7;11(11):792-804. doi: 10.1038/nrc3139.
Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression.
新兴临床证据表明，泛素介导的致癌基因产物或肿瘤抑制因子降解失调可能与癌和白血病的病因有关。最近的研究表明，三部分基序 (TRIM) 蛋白（RING 型 E3 泛素连接酶的一个亚家族）的某些成员作为癌发生的重要调节剂。本综述重点介绍了参与肿瘤发生和发展的 TRIM 蛋白。
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