Simeunović Slavko, Nedeljković Srećko, Milincić Zeljka, Vukotić Milija, Novaković Ivana, Majkić-Singh Nada, Nikolić Dejan, Risimić Dijana, Simeunović Dejan, Petronić Ivana, Radlović Vladimir
University Children's Hospital, Belgrade, Serbia.
Srp Arh Celok Lek. 2011 Jul-Aug;139(7-8):465-9.
Athersclerosis is a multifactorial disease that begins in childhood. There are few reports regarding influence of risk factors on the atherosclerotic processes in early period of life and adolescence.
The aim of this study was to present and analyze risk factor trends in school children over a 10-year period that were included and followed-up by the Yugoslav Study of Atherosclerosis Precursors in School Children (YUSAD Study).
There were three examinations of selected population from 13 centres. The first examination was performed when children were 10 years of age (first group; N = 6381 participants), the second examination on the same population when they were 15 years of age (second group; N = 5017) and third when children were 19/20 years of age (third group; N = 1293). Evaluated parameters included: BMI, waist circumference (WaC) and lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride).
A significant elevation of values (p < 0.001) of BMI, WaC and triglycerides and a significant decline (p < 0.001) of total cholesterol and LDL cholesterol in boys over 5 and 10-year period was noticed. There was a significant elevation (p < 0.001) of BMI, WaC and HDL values and a significant decline in LDL cholesterol values in girls over the 5 and 10-year period.
Our results point out that girls between 10 and 19/20 years have a better lipid profile during growth. It should be stressed out that childhood and adolescence can be more beneficial in the observation of risk factor influences on pathological, genetic and clinical levels.
动脉粥样硬化是一种始于儿童期的多因素疾病。关于危险因素对生命早期和青春期动脉粥样硬化进程影响的报道较少。
本研究的目的是呈现并分析南斯拉夫学龄儿童动脉粥样硬化前驱研究(YUSAD研究)纳入并随访的学龄儿童在10年期间的危险因素趋势。
对来自13个中心的选定人群进行了三次检查。第一次检查在儿童10岁时进行(第一组;N = 6381名参与者),第二次检查在同一人群15岁时进行(第二组;N = 5017),第三次检查在儿童19/20岁时进行(第三组;N = 1293)。评估参数包括:体重指数(BMI)、腰围(WaC)和血脂谱(总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯)。
在5年和10年期间,男孩的BMI、WaC和甘油三酯值显著升高(p < 0.001),总胆固醇和低密度脂蛋白胆固醇显著下降(p < 0.001)。在5年和10年期间,女孩的BMI、WaC和高密度脂蛋白值显著升高(p < 0.001),低密度脂蛋白胆固醇值显著下降。
我们的结果指出,10至19/20岁的女孩在生长过程中血脂谱较好。应该强调的是,在观察危险因素对病理、遗传和临床水平的影响方面,儿童期和青春期可能更有益。