对从桦剥管菌中分离出的作为干扰素诱导剂的RNA的研究。
Studies of RNA isolated from Piptoporus betulinus as interferon inducer.
作者信息
Kawecki Z, Kaczor J, Karpińska T, Sujak I, Kandefer-Szerszeń M
出版信息
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):517-22.
PMID:219808
Abstract
Crude RNA isolated from Piptoporus betulinus and two fractions of it obtained after the chromatography contain single-stranded RNA. The crude RNA, but not its chromatographic fractions, are resistant to the pancreatic RNA-ase. The crude preparation of RNA from P. betulinus contains beside ribose, considerable amounts of glucose, galactose and mannose. The crude RNA from P. betulinus induces in the human fibroblasts interferon with specific activity of 400 units per mg of protein.
摘要
从桦褐孔菌中分离得到的粗RNA及其经色谱分离后的两个组分均含有单链RNA。粗RNA对胰RNA酶具有抗性，但其色谱分离组分则不然。桦褐孔菌RNA的粗制品除核糖外，还含有大量的葡萄糖、半乳糖和甘露糖。桦褐孔菌的粗RNA可在人成纤维细胞中诱导产生干扰素，其比活性为每毫克蛋白质400单位。
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