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抗干扰素血清在研究致癌病毒中的应用。

Application of antisera to interferon in studying oncogenic viruses.

作者信息

Inglot A D, Oleszak E

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):529-36.

PMID:219809
Abstract

Susceptibility of BALB/c mice to infection with Moloney sarcoma virus (MSV) and to Herpes simplex virus type 2 (HSV-2) was considerably increased by administration of sheep anti-mouse interferon (anti-IF) serum. The regression of the MSV-induced tumors was inhibited when the weanling (three-to-four-week-old) mice were injected with the anti-IF serum. Using the anti-IF serum it has been found that the antagonism between HSV-2 and Rauscher leukemia virus in the mouse is not mediated by interferon. It is suggested that interferon is an important factor controlling growth of virus and/or virus induced tumor cells in the mouse before it develops a strong immunological response.

摘要

给BALB/c小鼠注射羊抗小鼠干扰素(抗IF)血清后,其对莫洛尼肉瘤病毒(MSV)感染和2型单纯疱疹病毒(HSV - 2)的易感性显著增加。当给断奶(3至4周龄)小鼠注射抗IF血清时,MSV诱导肿瘤的消退受到抑制。利用抗IF血清已发现,小鼠体内HSV - 2与劳斯氏白血病病毒之间的拮抗作用不是由干扰素介导的。有人提出,在小鼠产生强烈免疫反应之前,干扰素是控制病毒和/或病毒诱导肿瘤细胞生长的一个重要因素。

相似文献

1
Application of antisera to interferon in studying oncogenic viruses.抗干扰素血清在研究致癌病毒中的应用。
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):529-36.
2
Effects of anti-interferon serum on growth and regression of Moloney sarcoma virus induced tumours in mice.抗干扰素血清对小鼠莫洛尼肉瘤病毒诱导肿瘤生长和消退的影响。
Acta Biol Med Ger. 1979;38(5-6):829-35.
3
Tumor specific antigens in viral neoplasms and in unrelated virus infected tumors.病毒肿瘤及非相关病毒感染肿瘤中的肿瘤特异性抗原。
Ann Med Exp Biol Fenn. 1966;44(2):227-31.
4
Double infection of BALB/c mice with Rauscher murine leukemia and Herpes simplex virus type 2.
Arch Immunol Ther Exp (Warsz). 1980;28(2):337-44.
5
Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes.逆转录病毒引起的主要组织相容性复合体抗原表达变化影响细胞毒性T淋巴细胞介导的裂解敏感性。
J Immunol. 1985 Oct;135(4):2287-92.
6
In vitro studies of cell-mediated immunity to Moloney murine leukemia virus and Moloney leukemia-associated surface antigens.针对莫洛尼鼠白血病病毒和莫洛尼白血病相关表面抗原的细胞介导免疫的体外研究。
Cancer Res. 1979 Dec;39(12):4887-93.
7
Platelet-derived growth factor (PDGF) enhances the growth of Moloney sarcoma virus-induced tumors in mice.血小板衍生生长因子(PDGF)可促进莫洛尼氏肉瘤病毒诱导的小鼠肿瘤生长。
Arch Immunol Ther Exp (Warsz). 1981;29(4):431-7.
8
Increased oncogenicity of the murine sarcoma virus (Moloney) by co-infection with murine leukemia viruses.
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Monoclonal antibody against IFN-gamma inhibits Moloney murine sarcoma virus-specific cytotoxic T lymphocyte differentiation.抗γ干扰素单克隆抗体抑制莫洛尼氏鼠肉瘤病毒特异性细胞毒性T淋巴细胞分化。
J Immunol. 1988 Feb 15;140(4):1341-4.
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