钌催化的γ-杂原子取代β-酮酯的不对称氢化反应。
Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters.
机构信息
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
J Org Chem. 2011 Nov 18;76(22):9444-51. doi: 10.1021/jo201822k. Epub 2011 Oct 20.
PMID:21981465
Abstract
A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.
摘要
一系列对映体纯的γ-杂原子取代的β-羟基酯通过在 Ru-(S)-SunPhos 催化剂存在下氢化γ-杂原子取代的β-酮酯以高对映选择性（高达 99.1%ee）合成。这些不对称氢化反应为各种天然存在的和具有生物活性的化合物提供了关键的构建块。
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