Zhao Mengmeng, Li Wanfang, Li Xiaoming, Ren Kai, Tao Xiaoming, Xie Xiaomin, Ayad Tahar, Ratovelomanana-Vidal Virginie, Zhang Zhaoguo
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, China.
J Org Chem. 2014 Jul 3;79(13):6164-71. doi: 10.1021/jo5008916. Epub 2014 Jun 24.
A series of γ-hydroxy amides were synthesized with high enantioselectivities (up to 99%) using asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of naturally occurring and biologically active compounds.
在Ru-Xyl-SunPhos-Daipen催化剂存在下，通过相应γ-酮酰胺的不对称氢化反应，合成了一系列对映选择性高（高达99%）的γ-羟基酰胺，为多种天然存在的生物活性化合物提供了关键结构单元。
