钌（II）/木糖-三苯基膦/二异丙基乙胺对映选择性催化γ-酮酰胺的氢化反应
Enantioselective ruthenium(II)/Xyl-SunPhos/Daipen-catalyzed hydrogenation of γ-ketoamides.
作者信息
Zhao Mengmeng, Li Wanfang, Li Xiaoming, Ren Kai, Tao Xiaoming, Xie Xiaomin, Ayad Tahar, Ratovelomanana-Vidal Virginie, Zhang Zhaoguo
机构信息
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, China.
出版信息
J Org Chem. 2014 Jul 3;79(13):6164-71. doi: 10.1021/jo5008916. Epub 2014 Jun 24.
PMID:24933498
Abstract
A series of γ-hydroxy amides were synthesized with high enantioselectivities (up to 99%) using asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of naturally occurring and biologically active compounds.
摘要
在Ru-Xyl-SunPhos-Daipen催化剂存在下，通过相应γ-酮酰胺的不对称氢化反应，合成了一系列对映选择性高（高达99%）的γ-羟基酰胺，为多种天然存在的生物活性化合物提供了关键结构单元。
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