苯扎贝特对大鼠体内极低密度脂蛋白甘油三酯生成的长期影响。

Long-term effects of bezafibrate on in vivo VLDL-triglyceride production in the rat.

作者信息

Kazumi T, Yoshino G, Iwai M, Matsuba K, Matsushita M, Iwatani I, Kasama T, Yoshida M, Baba S

机构信息

Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan.

出版信息

Diabetes Res Clin Pract. 1990 May-Jun;9(2):163-8. doi: 10.1016/0168-8227(90)90108-6.

DOI:10.1016/0168-8227(90)90108-6

PMID:2198155

Abstract

Long-term effects of bezafibrate on in vivo production of VLDL-triglyceride were studied in the rat. Bezafibrate given at a daily dose of 30 mg/kg body weight for 14 days produced a decrease not only in triglyceride by 51% but in cholesterol by 28% and phospholipid by 18%. Despite a marked reduction in plasma triglyceride concentrations, there was no significant change in the rate of VLDL-triglyceride secretion from the liver into the circulation between bezafibrate-treated and control animals (1113 +/- 58 and 1234 +/- 63 micrograms/min, respectively). In addition, bezafibrate produced no change in lipid composition in VLDL. These results suggest that bezafibrate enhances triglyceride removal from the circulation, which leads to reduction in plasma triglyceride.

摘要

在大鼠中研究了苯扎贝特对极低密度脂蛋白甘油三酯体内生成的长期影响。以每日30毫克/千克体重的剂量给予苯扎贝特14天，不仅使甘油三酯降低了51%，胆固醇降低了28%，磷脂降低了18%。尽管血浆甘油三酯浓度显著降低，但在苯扎贝特治疗组和对照组动物之间，肝脏向循环中分泌极低密度脂蛋白甘油三酯的速率没有显著变化（分别为1113±58和1234±63微克/分钟）。此外，苯扎贝特对极低密度脂蛋白的脂质组成没有影响。这些结果表明，苯扎贝特可增强甘油三酯从循环中的清除，从而导致血浆甘油三酯降低。