Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.
Curr Opin Microbiol. 2011 Dec;14(6):691-7. doi: 10.1016/j.mib.2011.09.011. Epub 2011 Oct 5.
Cytokinesis in bacteria is mediated by a macromolecular machine known as the divisome, consisting of an assembly of FtsZ polymers around the cylindrical axis of the cell and the downstream regulators of division that are subsequently recruited to it. FtsZ polymerizes into filaments in a GTP-dependent manner, similarly to its eukaryotic structural homolog tubulin. The initial placement of the FtsZ polymerization site is tightly regulated by multiple mechanisms, as are the subsequent polymer reshaping and force generation that separate the two daughter cells from each other. New factors have been recently discovered that contribute to this regulation, notably affecting FtsZ polymer shaping, and modulating FtsZ polymerization in response to the metabolic or redox state of the cell.
细菌中的细胞分裂是由一种被称为分裂体的大分子机器介导的，该机器由围绕细胞圆柱轴组装的 FtsZ 聚合物和随后被招募到其上的分裂下游调节剂组成。FtsZ 以依赖 GTP 的方式聚合成长丝，类似于其真核结构同源物微管蛋白。FtsZ 聚合位点的初始放置受到多种机制的严格调节，随后的聚合物重塑和力的产生也将两个子细胞彼此分开。最近发现了新的因素有助于这种调节，特别是影响 FtsZ 聚合物的成型，并调节 FtsZ 聚合以响应细胞的代谢或氧化还原状态。
