Li G, Hansmann M L, Zwingers T, Lennert K
Department of Pathology, University of Kiel, West Germany.
Histopathology. 1990 Jun;16(6):519-31. doi: 10.1111/j.1365-2559.1990.tb01157.x.
Sixty-two cases of primary malignant lymphoma of the lung were investigated. Fifty-eight lymphomas were of B- and two of T-cell type. Two cases of high-grade lymphoma could not be further classified. The largest group (43 cases) consisted of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue. These showed features similar to low-grade B-cell lymphomas of the mucosa-associated lymphoid tissue of the stomach. The low-grade lymphomas showed a peak occurrence in the sixth decade, the high-grade lymphomas in the seventh decade. Males predominated slightly. Three-quarters of the patients with low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue showed solitary or multiple sharply defined nodules of the lung. The prognosis of the B-cell-derived lung lymphomas without constitutional symptoms was relatively favourable, regardless of whether they were of low- or high-grade malignancy, whereas patients with constitutional symptoms and the two patients with T-cell lymphomas showed a bad prognosis. However, recurrences and metastases in the lung, stomach, lymph nodes and salivary glands were seen in about 46% of the cases of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue.
对62例原发性肺恶性淋巴瘤进行了研究。其中58例为B细胞型淋巴瘤，2例为T细胞型淋巴瘤。2例高级别淋巴瘤无法进一步分类。最大的一组（43例）为支气管相关淋巴组织的低级别B细胞淋巴瘤。这些淋巴瘤表现出与胃黏膜相关淋巴组织的低级别B细胞淋巴瘤相似的特征。低级别淋巴瘤发病高峰在60岁，高级别淋巴瘤在70岁。男性略占多数。四分之三的支气管相关淋巴组织低级别B细胞淋巴瘤患者表现为肺部单个或多个边界清晰的结节。无全身症状的B细胞源性肺淋巴瘤，无论其恶性程度是低还是高，预后相对较好，而有全身症状的患者以及2例T细胞淋巴瘤患者预后较差。然而，在支气管相关淋巴组织低级别B细胞淋巴瘤病例中，约46%的患者出现肺、胃、淋巴结和唾液腺的复发和转移。
