Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
BMC Cancer. 2011 Oct 7;11:431. doi: 10.1186/1471-2407-11-431.
Serum selenium level (s-Se) has been associated with prostate cancer (PrCa) risk. We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se.
ULSAM, a population based Swedish male cohort (n = 2322) investigated at age 50 for s-Se and s-Se influencing factors: serum cholesterol, erythrocyte sedimentation rate and smoking habits. At age 71 a subcohort, (n = 1005) was genotyped for OGG1 and MnSOD polymorphisms.
In a 34-year-follow-up, national registries identified 208 PrCa cases further confirmed in medical records. Participants with s-Se in the upper tertile had a non-significantly lower risk of PrCa. Smokers with s-Se in the two lower tertiles (≤80 μg/L) experienced a higher cumulative incidence of PrCa than smokers in the high selenium tertile (Hazard Ratio 2.39; 95% CI: 1.09-5.25). A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa.
S-Se levels and smoking habits influence long-term risk of PrCa. Smoking as a risk factor for PrCa in men with low s-Se is relevant to explore further. Exploratory analyses of variations in OGG1 and MnSOD genes indicate that hypotheses about patterns of exposure to selenium and smoking combined with data on genetic variation in genes involved in DNA repair can be valuable to pursue.
血清硒水平（s-Se）与前列腺癌（PrCa）风险有关。我们研究了 s-Se、吸烟和非筛查发现的 PrCa 之间的关系，并探讨了两个 DNA 修复基因：OGG1 和 MnSOD 中的多态性是否影响 s-Se 的任何作用。
ULSAM 是一项基于人群的瑞典男性队列研究（n=2322），在 50 岁时检测 s-Se 及其影响因素：血清胆固醇、红细胞沉降率和吸烟习惯。在 71 岁时，一个亚队列（n=1005）进行了 OGG1 和 MnSOD 多态性的基因分型。
在 34 年的随访中，国家登记处确定了 208 例前列腺癌病例，并在病历中进一步证实。s-Se 处于上三分位的参与者患前列腺癌的风险略低。s-Se 处于两个较低三分位（≤80μg/L）的吸烟者比处于高硒三分位的吸烟者患前列腺癌的累积发生率更高（危险比 2.39；95%CI：1.09-5.25）。OGG1 基因 rs125701 非野生型与吸烟状态相结合或 MnSOD 基因 rs4880 相关变异与高三分位硒相结合，似乎能预防前列腺癌。
s-Se 水平和吸烟习惯影响前列腺癌的长期风险。进一步探讨低 s-Se 男性中吸烟作为前列腺癌危险因素的相关性是有意义的。对 OGG1 和 MnSOD 基因变异的探索性分析表明，关于暴露于硒和吸烟模式的假设以及涉及 DNA 修复的基因的遗传变异数据可能具有重要意义。
