Ashor Ammar W
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Neurosciences (Riyadh). 2011 Oct;16(4):353-7.
Exploration of the variable effect of the degree of smoking dependence on psychomotor performance and working memory capacity.
This is a randomized, controlled, prospective study conducted in the Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq from 15 January 2011 to 25 February 2011. After third stage male medical students completed the Fagerstrom Test for Nicotine Dependence questionnaire, we randomly selected a sample of 32 students and divided them into 3 groups: 10 participants with zero score (non-smokers), 11 participants with a score of 5 or less (light smokers), and 11 participants with a score of 6 or more (heavy smokers). Choice reaction time and flicker fusion were measured by the Leeds psychomotor performance test battery, and working memory capacity was measured by the N-back working memory test.
We found significant improvement in ascending flicker fusion test in heavy smokers in comparison with non-smokers (p=0.005, confidence interval [CI] 0.99-6), and light smokers (p=0.053, CI 0.39-4.5). Heavy smokers significantly deteriorated in the 3-back task in comparison with non-smokers (p=0.006, CI 4-25.8), and light smokers (p=0.009, CI 3-24.4). No significant changes were seen between groups in the descending critical flicker fusion, the components of choice reaction time, and in 1-, 2- back working memory tests.
Heavy smoking (high nicotine) enhances arousal, but impairs working memory capacity.
探讨吸烟依赖程度对心理运动表现和工作记忆能力的不同影响。
这是一项随机、对照、前瞻性研究，于2011年1月15日至2011年2月25日在伊拉克巴格达穆斯坦西里亚大学医学院药理学系进行。三年级男医学生完成尼古丁依赖的法格斯特龙测试问卷后，我们随机抽取32名学生作为样本，将他们分为3组：10名得分为零的参与者（非吸烟者）、11名得分为5分或以下的参与者（轻度吸烟者）和11名得分为6分或以上的参与者（重度吸烟者）。通过利兹心理运动表现测试电池测量选择反应时间和闪烁融合，通过N-back工作记忆测试测量工作记忆能力。
我们发现，与非吸烟者相比，重度吸烟者在上升闪烁融合测试中有显著改善（p = 0.005，置信区间[CI]0.99 - 6），与轻度吸烟者相比也有改善（p = 0.053，CI 0.39 - 4.5）。与非吸烟者相比，重度吸烟者在3-back任务中显著恶化（p = 0.006，CI 4 - 25.8），与轻度吸烟者相比也恶化（p = 0.009，CI 3 - 24.4）。在下降临界闪烁融合、选择反应时间的组成部分以及1-back、2-back工作记忆测试中，各组之间未观察到显著变化。
重度吸烟（高尼古丁）会增强唤醒，但会损害工作记忆能力。
