Luke B, Keith L G
Department of Gynecology and Obstetrics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.
J Reprod Med. 1990 Jul;35(7):667-73.
All newborn infants, male and female, have been screened for phenylketonuria (PKU) since 1961. Medical therapy is generally continued until age 6. The first cohort of treated females reached reproductive age 15 years ago, and new members are joining this cohort annually. This paper reviews the implications of childbearing in women who were treated for PKU as children and are no longer under treatment. Untreated maternal PKU can lead to mental retardation in utero.
自1961年以来，所有新生儿，无论男女，都接受了苯丙酮尿症（PKU）筛查。医学治疗通常持续到6岁。首批接受治疗的女性在15年前达到了生育年龄，并且每年都有新成员加入这个队列。本文综述了儿童期接受PKU治疗且现已停止治疗的女性生育的影响。未经治疗的母亲患苯丙酮尿症可导致子宫内胎儿智力发育迟缓。
