Larichev A B, Shishlo V K, Lisovskiĭ A V, Chistiakov A L
Khirurgiia (Mosk). 2011(7):31-5.
The study covers treatment results of 220 patients operated on ventral hernia and in vivo experimental treatment of 36 rats proved the nitrogen monoxide (NO) to be the effective means of wound infection prophylaxis. NO potentiates antiseptic effects, minimizing intraoperative wound contamination. It, besides, stimulates endothelial and basal cells of epidermis proliferation. Wound infection was observed only in 9,8% of patients, treated with NO intraoperatively. All cases of infective complications were serous and infiltrative, but not purulent.
该研究涵盖了220例接受腹疝手术患者的治疗结果，对36只大鼠进行的体内实验治疗证明一氧化氮（NO）是预防伤口感染的有效手段。NO可增强抗菌效果，将术中伤口污染降至最低。此外，它还能刺激表皮的内皮细胞和基底细胞增殖。术中接受NO治疗的患者中，仅9.8%观察到伤口感染。所有感染并发症均为浆液性和浸润性，而非脓性。
