Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital, North Kargar Ave., 14114, Tehran, Iran.
Endocrine. 2012 Feb;41(1):144-51. doi: 10.1007/s12020-011-9537-3. Epub 2011 Oct 9.
To investigate the effect of heavy resistance exercise on IGF-1 system, 19 healthy trained men and 15 healthy untrained men volunteered to participate in this study. The subjects were randomly divided into experimental and control groups. Subjects of experimental groups were forced to perform a heavy resistance exercise with the intensity of 70-80% of 1RM in selected movements. The blood samples were taken from all subjects four times; before (T1), immediately after (T2), 5 (T3), and 8 (T4) hours after exercise. Analysis of data showed that a session of heavy resistance exercise induced significant increase in GH at T2 (P < 0.05) and a significant decrease in insulin at T4 (P < 0.05) and a significant decrease in IGFBP3 at T4 (P < 0.05) in trained group. In untrained group, no significant change in any of the variables was observed. However, the procedure of response in variables was almost similar in two experimental groups. Although, the exercise did not appreciably affect IGF-1 levels, it decreased in all groups at length of time after exercise. In addition, the exercise did not have any notable effect on IGFBP1 levels over time. In conclusion, the findings of this study indicate that the intense resistance exercise can lead to changes in blood concentrations of IGF-1 system components which are observable in blood circulation over time and the amounts of changes depend on subjects' fitness levels and exercise variables.
为了研究大阻力运动对 IGF-1 系统的影响，19 名健康的训练有素的男性和 15 名健康的未训练的男性志愿者参与了这项研究。这些受试者被随机分为实验组和对照组。实验组的受试者被迫在选定的运动中以 1RM 的 70-80%的强度进行大阻力运动。所有受试者在运动前（T1）、运动后即刻（T2）、5 小时（T3）和 8 小时（T4）四次采集血液样本。数据分析表明，一次大阻力运动导致 T2 时 GH 显著升高（P<0.05），T4 时胰岛素显著降低（P<0.05），IGFBP3 显著降低（P<0.05）。在未训练组中，没有观察到任何变量的显著变化。然而，两个实验组的变量反应过程几乎相似。尽管运动对 IGF-1 水平没有明显影响，但运动后一段时间内所有组的 IGF-1 水平都下降了。此外，运动对 IGFBP1 水平的影响在整个时间过程中并不显著。总之，这项研究的结果表明，剧烈的阻力运动可以导致 IGF-1 系统成分在血液中的浓度发生变化，这些变化在血液循环中可以随时间观察到，并且变化的程度取决于受试者的健康水平和运动变量。
