Rubin Daniela A, Pham Hoang N, Adams Eric S, Tutor Andrew R, Hackney Anthony C, Coburn Jared W, Judelson Daniel A
Department of Kinesiology, California State University, 800 N. State College Blvd., Fullerton, CA, 92834, USA,
Eur J Appl Physiol. 2015 Jun;115(6):1359-66. doi: 10.1007/s00421-015-3105-0. Epub 2015 Jan 30.
Resistance exercise induces a host of endocrine responses that potentiate its effects on body composition and metabolism. Excess adiposity negatively affects some hormonal responses to exercise in sedentary men. This study compared the resistance exercise (RE)-associated growth hormone (GH), insulin-like growth factor-1 (IGF-1), and testosterone responses in lean vs. obese physically active men.
Ten healthy physically active obese males (body fat % 36.2 ± 4.03, age 24.6 ± 3.7 years, mass 104.5 ± 15.5 kg, height 178.8 ± 6.0 cm) were compared to ten lean counterparts (body fat % 12.7 ± 2.9, age 24.6 ± 3.7 years, mass 77.1 ± 6.4 kg, height 177.2 ± 4.8 cm). The muscular endurance RE protocol consisted of six sets of ten repetitions per leg of stepping onto an elevated platform (20 % of participant's height) while wearing a weighted-vest (50 % of participant's lean mass). Pre-, immediately post-exercise (IP), and three more blood samples were collected during the one-hour recovery.
When accounting for baseline differences there were no group by time interactions for GH (p = 0.33); or LH (p = 0.52). Lean presented a trend towards significance for higher IGF-1 IP (p = 0.08) than obese. Testosterone IP was similar in obese and lean, but lower in obese than lean at 30 min into recovery (p < 0.01). AUC were lower in obese than lean for all hormones (p < 0.05 for all).
These findings suggest that excess adiposity does not appear to negatively affect the immediate GH and T responses to RE in active males; but possibly negatively affects IGF-1. However, the baseline and integrated concentrations during recovery appear negatively affected by excess adiposity.
抗阻运动可引发一系列内分泌反应，增强其对身体成分和新陈代谢的影响。肥胖会对久坐男性运动时的某些激素反应产生负面影响。本研究比较了身体活动的瘦体重男性与肥胖男性在抗阻运动（RE）过程中生长激素（GH）、胰岛素样生长因子-1（IGF-1）和睾酮的反应。
将10名健康且身体活动的肥胖男性（体脂率36.2±4.03%，年龄24.6±3.7岁，体重104.5±15.5千克，身高178.8±6.0厘米）与10名瘦体重男性（体脂率12.7±2.9%，年龄24.6±3.7岁，体重77.1±6.4千克，身高177.2±4.8厘米）进行比较。肌肉耐力抗阻运动方案包括穿着加重背心（占参与者瘦体重的50%），每条腿踏上一个升高平台（参与者身高的20%），每组10次重复，共进行6组。在运动前、运动后即刻（IP）以及恢复的1小时内再采集3次血样。
在考虑基线差异后，GH（p = 0.33）和促黄体生成素（LH，p = 0.52）不存在组间与时间的交互作用。瘦体重男性运动后即刻的IGF-1有高于肥胖男性的显著趋势（p = 0.08）。肥胖男性和瘦体重男性运动后即刻的睾酮水平相似，但在恢复30分钟时，肥胖男性低于瘦体重男性（p < 0.01）。所有激素的曲线下面积（AUC）肥胖男性均低于瘦体重男性（所有p < 0.05）。
这些结果表明，肥胖似乎不会对活跃男性运动后即刻的GH和睾酮反应产生负面影响；但可能对IGF-1有负面影响。然而，恢复过程中的基线和综合浓度似乎受到肥胖负面影响。
