Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, UK.
Nat Immunol. 2011 Oct 9;12(11):1071-7. doi: 10.1038/ni.2133.
Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.
白细胞介素 9（IL-9）是一种与肺部炎症相关的细胞因子，但它的细胞起源和功能仍不清楚。在这里，我们描述了一种报告小鼠品系，用于绘制已经激活白细胞介素 9 的细胞的命运图。我们发现，在木瓜蛋白酶诱导的肺部炎症中，白细胞介素 9 的产生主要局限于固有淋巴细胞（ILC）。ILC 产生白细胞介素 9 依赖于适应性免疫细胞的 IL-2，并迅速被其他细胞因子（如白细胞介素 13 和白细胞介素 5）取代。通过中和抗体阻断白细胞介素 9 的产生导致白细胞介素 13 和白细胞介素 5 的表达水平降低很多，这表明 ILC 提供了在调节 2 型辅助 T 细胞细胞因子和反应方面 IL-9 功能的缺失环节。
