Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Biochem Genet. 2012 Apr;50(3-4):298-308. doi: 10.1007/s10528-011-9472-2. Epub 2011 Oct 9.
This study investigated the association of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) with type 2 diabetes with or without metabolic syndrome in Malaysia. Nine HNF4 alpha SNPs were genotyped in 390 type 2 diabetic subjects with metabolic syndrome, 135 type 2 diabetic subjects without metabolic syndrome, and 160 control subjects. The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively). The 6-SNP haplotype2 CCCGTC containing the risk genotype of these SNPs was associated with higher risk for type 2 diabetes with or without metabolic syndrome (P = 0.002, OR 2.2; P = 0.004, OR 3.1). These data suggest that HNF4 alpha SNPs and haplotypes contributed to increased type 2 diabetes risk in the Malaysian population.
本研究旨在探讨马来西亚人群中肝细胞核因子 4 (HNF4)α单核苷酸多态性 (SNP) 与伴或不伴代谢综合征的 2 型糖尿病之间的关联。在 390 例伴代谢综合征的 2 型糖尿病患者、135 例不伴代谢综合征的 2 型糖尿病患者和 160 例对照者中，共检测了 9 个 HNF4αSNP。SNP rs4810424、rs1884613 和 rs2144908 与不伴代谢综合征的 2 型糖尿病的保护作用相关（隐性 P=0.018，OR 0.32；P=0.004，OR 0.25；P=0.005，OR 0.24）。包含这些 SNP 风险基因型的 6-SNP 单倍型 2 CCCGTC 与伴或不伴代谢综合征的 2 型糖尿病风险增加相关（P=0.002，OR 2.2；P=0.004，OR 3.1）。这些数据表明，HNF4αSNP 和单倍型增加了马来西亚人群 2 型糖尿病的风险。
